Evidence map›Paper›PMID 33164151›Full record

ReviewAnalytical and bioanalytical chemistry2021

Recent advances in nanomaterial-based biosensors for the detection of exosomes.

Linan Zhang, Chunchuan Gu, Jiajun Wen, Guangxian Liu, Hongying Liu, Lihua Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
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  14. A review of spectroscopic probes constructed from aptamer-binding gold/silver nanoparticles or their dimers in environmental pollutants' detection.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2022
    Review
  15. Review
  16. Review
  17. Exosome Processing and Characterization Approaches for Research and Technology Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  18. Review
  19. Article
  20. Aptasensors for Cancerous Exosome Detection.Methods in molecular biology (Clifton, N.J.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Linan Zhang *Hangzhou Dianzi University, Hangzhou, 310018, Zhejiang, China.
Chunchuan Gu *Department of Clinical Laboratory, Hangzhou Cancer Hospital, Hangzhou, 310002, Zhejiang, China.
Jiajun WenHangzhou Dianzi University, Hangzhou, 310018, Zhejiang, China.
Guangxian LiuHangzhou Dianzi University, Hangzhou, 310018, Zhejiang, China.
Hongying LiuHangzhou Dianzi University, Hangzhou, 310018, Zhejiang, China. liuhongying@hdu.edu.cn.
Lihua LiHangzhou Dianzi University, Hangzhou, 310018, Zhejiang, China. lilh@hdu.edu.cn.

Funding

National Natural Science Foundation of China 21405029
6 · The paper itself

Abstract

Exosomes are a type of extracellular vesicle actively secreted by almost all eukaryotic cells. They are ideal candidates for reliable next-generation biomarkers in the early diagnosis and therapeutic response evaluation of cancer. Thus, the quantification of exosomes is crucial in facilitating clinical research and application. Compared with traditional materials, nanomaterials have better optical, magnetic, electrical, and catalytic properties due to their small size, high specific surface area, and variable structure. The incorporation of nanomaterials into sensing systems is an attractive approach towards improving sensitivity and can provide improved sensor selectivity and stability. In this paper, we summarize the progress in nanomaterial-based exosome detection methods, including electrochemical biosensors, photoelectrochemical biosensors, colorimetric biosensors, fluorescence biosensors, chemiluminescence biosensors, electrochemiluminescence biosensors, surface plasmon resonance biosensors, and surface-enhanced Raman spectroscopy biosensors. Moreover, future research directions and challenges in exosome detection methods are discussed. We hope that this article will offer an overview of nanomaterial-based exosome detection techniques and open new avenues in disease research.Graphical abstract.

Indexed as

Biosensing TechniquesNanostructuresElectrochemical TechniquesExosomesHumansLiquid BiopsyNeoplasmsSpectrum AnalysisElectrochemical biosensorExosomeNanomaterialOptical biosensor

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.