ArticleMatter2021
Comparative Analysis of Nanomechanical Features of Coronavirus Spike Proteins and Correlation with Lethality and Infection Rate.
Article in Matter, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Unveiling the Structural and Mechanical Diversity of SARS-CoV-2 Variants Using Atomic Force Microscopy.ACS applied materials & interfaces · 2026Article
- Principles and Therapeutics ofJournal of pharmacy & bioallied sciences · 2024Review
- Nanomechanical analysis of SARS-CoV-2 variants and predictions of infectiousness and lethality.Soft matter · 2022Article
- Finite element modeling of α-helices and tropocollagen molecules referring to spike of SARS-CoV-2.Biophysical journal · 2022Article
- Rapid prediction of protein natural frequencies using graph neural networks.Digital discovery · 2022Article
- Modeling coronavirus spike protein dynamics: implications for immunogenicity and immune escape.Biophysical journal · 2021Article
- Article
- Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods.Biophysical chemistry · 2021Article
- Effect of receptors on the resonant and transient harmonic vibrations of Coronavirus.Journal of the mechanics and physics of solids · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The novel coronavirus disease 2019 (COVID-19) has spread rapidly around the world. Its causative virus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), enters human cells through the physical interaction between the receptor-binding domain (RBD) of its spike protein and the human cell receptor ACE2. Here, we provide a novel way of understanding coronavirus spike proteins, connecting their nanomechanical features, specifically their vibrational spectrum and quantitative measures of mobility, with virus lethality and infection rate. The key result of our work is that both the overall flexibility of upward RBD and the mobility ratio of RBDs in different conformations represent two significant factors that show a positive scaling with virus lethality and an inverse correlation with the infection rate. Our analysis shows that epidemiological virus properties can be linked directly to pure nanomechanical, vibrational aspects, offering an alternative way of screening new viruses and mutations, and potentially exploring novel ways to prevent infections from occurring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.