Evidence map›Paper›PMID 33163909›Full record

ArticleACS applied nano materials2020

Complex Relationship Between Iron Oxide Nanoparticle Degradation and Signal Intensity in Magnetic Particle Imaging.

Julia Guzy, Shatadru Chakravarty, Foster J Buchanan, Haoran Chen, Jeffrey M Gaudet, Jeremy M L Hix, Christiane L Mallett, Erik M Shapiro

Abstract read
In one paragraph

Article in ACS applied nano materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Elucidating Iron Metabolism through Molecular Imaging.Current issues in molecular biology · 2024
    Review
  8. Application of magnetic particle imaging to evaluate nanoparticle fate in rodent joints.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. 3DFrontiers in cell and developmental biology · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia GuzyDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Shatadru ChakravartyDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Foster J BuchananDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Haoran ChenDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Jeffrey M GaudetInstitute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Jeremy M L HixDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Christiane L MallettDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.
Erik M ShapiroDepartment of Radiology and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.

Funding

Quantitative molecular and cellular MRI of hepatocyte transplantationR01DK107697 · NIDDK · MICHIGAN STATE UNIVERSITY · PI SHAPIRO, ERIK · 2015 to 2018
$2.1M
NIDDK NIH HHS R01 DK107697
6 · The paper itself

Abstract

Magnetic particle imaging (MPI), using superparamagnetic nanoparticles as an imaging tracer, is touted as a quantitative biomedical imaging technology, but MPI signal properties have never been characterized for magnetic nanoparticles undergoing biodegradation. We show that MPI signal properties can increase or decrease as iron oxide nanoparticles degrade, depending on the nanoparticle formulation and nanocrystal size, and degradation rate and mechanism. Further, we show that long-term in vitro MPI experiments only roughly approximate long-term in vivo MPI signal properties. Further, we demonstrate for the first time, an environmentally sensitive MPI contrast mechanism opening the door to smart contrast paradigms in MPI.

Indexed as

biodegradationcontrast agentsiron oxideMagnetic Particle Imagingnanoparticles

Identifiers

PMID33163909
PMCPMC7643918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.