ArticleNorthern clinics of Istanbul2020
The musculoskeletal system manifestations in children with familial Mediterranean fever.
Article in Northern clinics of Istanbul, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Neurological involvement in children with familial Mediterranean fever: a systematic review.Pediatric rheumatology online journal · 2025Pooled it
- Protracted febrile myalgia syndrome in children with familial Mediterranean fever - systematic review and a case report.Pediatric rheumatology online journal · 2024Pooled it
- Case Report: Acute Sarcoid Myositis Mimicking Protracted Febrile Myalgia in Familial Mediterranean Fever.International journal of rheumatic diseases · 2026Article
- Subclinical inflammation in pediatric familial Mediterranean fever: predictors and follow-up results of a retrospective single-center cohort study.Clinical rheumatology · 2026Article
- Comparative analysis of exon 10 and non-exon 10 variants in children with familial mediterranean fever: a retrospective cohort study.European journal of pediatrics · 2026Article
- The impact of homozygous mutations in exon 10 on musculoskeletal findings in children with familial mediterranean fever.European journal of pediatrics · 2025Article
- Physical fitness in adolescent patients with familial Mediterranean fever.Rheumatology international · 2024Article
- Familial Mediterranean Fever in Childhood.Turkish archives of pediatrics · 2024Review
- The Impact of Different MEFV Genotypes on Clinical Phenotype of Patients with Familial Mediterranean Fever: Special Emphasis on Joint Involvement.European journal of pediatrics · 2024Article
- Comparison of the clinical diagnostic criteria and the results of the next-generation sequence gene panel in patients with monogenic systemic autoinflammatory diseases.Clinical rheumatology · 2021Article
- Real-Life Data From the Largest Pediatric Familial Mediterranean Fever Cohort.Frontiers in pediatrics · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveFamilial Mediterranean fever (FMF) is a monogenic inherited periodic fever syndrome presenting with episodes of self-limiting fever and inflammation of serosal membranes. Besides the findings in the diagnostic criteria, musculoskeletal findings can also be seen in FMF patients attacks. In this study, we aim to reveal the frequency and genotype association of musculoskeletal manifestations in children with FMF.
methodsThe patients diagnosed with FMF between January 1, 2017 and June 1, 2019, and followed for at least six months in our pediatric rheumatology clinic were included in this study. Musculoskeletal manifestations of patients were enrolled. The patients were grouped according to the "Mediterranean Fever" (MEFV) gene variants. Musculoskeletal manifestations of the patients were compared between the groups.
resultsThe study group included 634 children with FMF (336 female and 298 male, F/M: 1.13/1). The clinical manifestations of patients in the attack period were as follows: 99% of the patients had a fever, 87.3% had abdominal pain, 20.7% had chest pain, 11.3% had vomiting, 10.7% had erysipelas like erythema, and 9.3% had a headache. The musculoskeletal symptoms were accompanied by 58.6% (n=372) of the patients during the attack period. The most common musculoskeletal manifestation was found as arthralgia (32.6%, n=206). Also, the other musculoskeletal manifestations were as follows during attacks: arthritis in 23.7% (n=150), myalgia in 20.5% (n=130), exertional leg pain in 6.5% (n=41), and protracted febrile myalgia in 1% (n=7) of the patients. It was observed that the musculoskeletal manifestations were significantly higher in patients with homozygous M694V variants in exon-10 (p=0.017). The musculoskeletal manifestations were more common in the attack periods of patients carrying the M694V variant in at least one allele (p=0.019).
conclusionWe found that the musculoskeletal manifestations were accompanied in more than half of patients with FMF. M694V variant was found as a risk factor for emerging musculoskeletal manifestations.
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