Evidence map›Paper›PMID 33163831›Full record

ArticleHepatology communications2020

Loss of Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Links Nonalcoholic Steatohepatitis to Atherosclerosis.

Hilda E Ghadieh, Raghd Abu Helal, Harrison T Muturi, Daniella D Issa, Lucia Russo, Simon L Abdallah, John A Najjar, Fabian Benencia, Guillermo Vazquez, Wei Li and 1 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Regulation of lipid storage and inflammation in the liver by CEACAM1.European journal of clinical investigation · 2024
    Review
  4. CEACAM1 in vascular homeostasis and inflammation.European journal of clinical investigation · 2024
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Hilda E GhadiehCenter for Diabetes and Endocrine Research University of Toledo College of Medicine and Life Sciences Toledo OH USA.
Raghd Abu HelalDepartment of Biomedical Sciences Ohio University Athens OH USA.
Harrison T MuturiCenter for Diabetes and Endocrine Research University of Toledo College of Medicine and Life Sciences Toledo OH USA.
Daniella D IssaDepartment of Biomedical Sciences Ohio University Athens OH USA.
Lucia RussoCenter for Diabetes and Endocrine Research University of Toledo College of Medicine and Life Sciences Toledo OH USA.
Simon L AbdallahCenter for Diabetes and Endocrine Research University of Toledo College of Medicine and Life Sciences Toledo OH USA.
John A NajjarCenter for Diabetes and Endocrine Research University of Toledo College of Medicine and Life Sciences Toledo OH USA.
Fabian BenenciaDepartment of Biomedical Sciences Ohio University Athens OH USA.
Guillermo VazquezCenter for Diabetes and Endocrine Research University of Toledo College of Medicine and Life Sciences Toledo OH USA.
Wei LiDepartment of Biomedical Sciences Marshall University Joan C. Edwards School of Medicine Huntington WV USA.
Sonia M NajjarCenter for Diabetes and Endocrine Research University of Toledo College of Medicine and Life Sciences Toledo OH USA.
Ohio University · USUniversity of Toledo · USMarshall University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI Travis Salisbury · 2012 to 2026
$61.1M
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Thymidine Phosphorylase: a Novel Target of Antiplatelet TherapyR15HL145573 · NHLBI · MARSHALL UNIVERSITY · PI LI, WEI · 2019 to 2022
$878k
NHLBI NIH HHS R15 HL145573NIDDK NIH HHS P30 DK045735NIGMS NIH HHS P20 GM103434NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Patients with nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) commonly develop atherosclerosis through a mechanism that is not well delineated. These diseases are associated with steatosis, inflammation, oxidative stress, and fibrosis. The role of insulin resistance in their pathogenesis remains controversial. Albumin (

Identifiers

PMID33163831
PMCPMC7603529
OpenAlexW3081722189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.