Evidence map›Paper›PMID 33163713›Full record

ArticleKidney international reports2020

Endothelin Type A Receptor Antibodies Are Associated With Angiotensin II Type 1 Receptor Antibodies, Vascular Inflammation, and Decline in Renal Function in Pediatric Kidney Transplantation.

Meghan H Pearl, Lucia Chen, Rim ElChaki, David Elashoff, David W Gjertson, Maura Rossetti, Patricia L Weng, Qiuheng Zhang, Elaine F Reed, Eileen Tsai Chambers

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  8. Antibodies to angiotensin II type 1 receptor and endothelin type A receptor are associated with cytokine production enriched for type 2 immune response and antibody production in pediatric kidney transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  9. Review
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  12. Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Meghan H PearlDivision of Pediatric Nephrology, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
Lucia ChenDepartment of Medicine Statistics Core, University of California Los Angeles, Los Angeles, California, USA.
Rim ElChakiDivision of Pediatric Nephrology, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
David ElashoffDepartment of Medicine Statistics Core, University of California Los Angeles, Los Angeles, California, USA.
David W GjertsonDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, USA.
Maura RossettiDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, USA.
Patricia L WengDivision of Pediatric Nephrology, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
Qiuheng ZhangDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, USA.
Elaine F ReedDepartment of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, California, USA.
Eileen Tsai ChambersDivision of Pediatric Nephrology, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
University of California, Los Angeles · USDuke University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Regulation of Innate Immune Responses by Alloimmunity in Liver Ischemia-Reperfusion InjuryP01AI120944 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David Gjertson · 2017 to 2026
$20.0M
Project 3: Mapping the Evolution of Chronic Transplant Injury in the Context of CMV InfectionU19AI128913 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELASHOFF, DAVID · 2017 to 2021
$11.2M
Systems Immunolobiology of Antibiotic-Persistent MRSA InfectionU01AI124319 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2020
$10.1M
The role of HLA and its coreceptors in endothelial cell activation and leukocyte recruitment in antibody-mediated transplant rejectionR01AI135201 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert L Fairchild, ELAINE F REED · 2018 to 2026
$5.3M
Understanding the Interface of Allo and Auto-Immunity: The Impact of Angiotensin II Type 1 Receptor Antibodies in Pediatric Kidney Transplant RecipientsK23AI139335 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PEARL, MEGHAN HALEY · 2019 to 2023
$1.0M
Translational Research Training in Pediatric NephrologyT32DK104687 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SALUSKY, ISIDRO B. · 2015 to 2019
$879k
NCATS NIH HHS UL1 TR001881NIAID NIH HHS K23 AI139335NIAID NIH HHS P01 AI120944NIAID NIH HHS R01 AI135201NIAID NIH HHS U01 AI124319NIAID NIH HHS U19 AI128913NIDDK NIH HHS T32 DK104687
6 · The paper itself

Abstract

introductionAutoantibody to angiotensin II type 1 receptor (AT1R-Ab) has been recognized as a non-human leukocyte antigen (HLA) antibody relevant in transplantation. Endothelin type A receptor antibody (ETAR-Ab) has been strongly associated with AT1R-Ab, but the data in kidney transplantation are scarce.

methodsWe examined the relationship of ETAR-Ab and AT1R-Ab with clinical outcomes, biopsy findings, inflammatory cytokines, and HLA donor-specific antibody (DSA) in a cohort of pediatric renal transplant recipients. Sixty-five patients were longitudinally monitored for ETAR-Ab, AT1R-Ab, HLA DSA, interleukin (IL)-8, tumor necrosis factor-α, IL-1β, interferon-γ, IL-17, IL-6, renal dysfunction, hypertension, rejection, and allograft loss during the first 2 years post-transplant.

resultsFifteen patients (23%) had AT1R-Ab alone, 1 (2%) had ETAR-Ab alone, 23 (35%) had both ETAR-Ab and AT1R-Ab, and 26 (40%) were negative for both antibodies at all timepoints. Having both ETAR-Ab and AT1R-Ab was associated with >30% decline in estimated glomerular filtration rate (

conclusionOur study demonstrates that, in pediatric kidney transplantation, ETAR-Ab is highly associated with AT1R-Ab, but there are a subset of patients with AT1R-Ab alone. Having both antibodies is significantly associated with arteritis, elevated IL-8, and decline in renal function, and our results suggest possible interaction effects. Better understanding of this interaction may be informative in developing protocols for testing, treatment, and prevention of allograft injury.

Indexed as

angiotensin II type 1 receptor antibodycytokineendothelin type A receptor antibodyhuman leukocyte antigen donor-specific antibodypediatric nephrologytransplantation

Identifiers

PMID33163713
PMCPMC7609952
OpenAlexW3083324517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.