Evidence map›Paper›PMID 33163698›Full record

ArticleBioactive materials2021

Enlisting a Traditional Chinese Medicine to tune the gelation kinetics of a bioactive tissue adhesive for fast hemostasis or minimally invasive therapy.

Haoqi Tan, Dawei Jin, Junjie Sun, Jialin Song, Yao Lu, Meng Yin, Xin Chen, Xue Qu, Changsheng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haoqi TanKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Dawei JinDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.
Junjie SunKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jialin SongKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Yao LuKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Meng YinDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, China.
Xin ChenKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Xue QuKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Changsheng LiuKey Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gelation kinetics is important in tailoring chemically crosslinked hydrogel-based injectable adhesives for different applications. However, the regulation of gelation rate is usually limited to varying the gel precursor and/or crosslinker concentration, which cannot reach a fine level and inevitably alters the physical properties of hydrogels. Amidation reactions are widely used to synthesize hydrogel adhesives. In this work, we propose a traditional Chinese medicine (Borax)-input strategy to tune the gelation rate of amidation reaction triggered systems. Borax provides an initial basic buffer environment to promote the deprotonation process of amino groups and accelerate this reaction. By using a tissue adhesive model PEG-lysozyme (PEG-LZM), the gelation time can be modulated from seconds to minutes with varying Borax concentrations, while the physical properties remain constant. Moreover, the antibacterial ability can be improved due to the bioactivity of Borax. The hydrogel precursors can be regulated to solidify instantly to close the bleeding wound at emergency. Meanwhile, they can also be customized to match the flowing time in the catheter, thereby facilitating minimally invasive tissue sealing. Because this method is easily operated, we envision Borax adjusted amidation-type hydrogel has a promising prospect in clinical application.

Indexed as

BoraxGelation timeInjectable tissue adhesiveMinimally invasive deliveryRapid hemostasis

Identifiers

PMID33163698
PMCPMC7599438

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.