Evidence map›Paper›PMID 33163507›Full record

ArticleHepatobiliary surgery and nutrition2020

Liver venous deprivation versus portal vein embolization before major hepatectomy: future liver remnant volumetric and functional changes.

Boris Guiu, François Quenet, Fabrizio Panaro, Lauranne Piron, Christophe Cassinotto, Astrid Herrerro, François-Régis Souche, Margaux Hermida, Marie-Ange Pierredon-Foulongne, Ali Belgour and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Hepatobiliary surgery and nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 6 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. SURGICAL TECHNIQUES TO INCREASE RESECTABILITY IN LIVER METASTASIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Boris GuiuDepartment of Radiology, St-Eloi University Hospital, Montpellier, France.
François QuenetDepartment of Surgery, Institut du Cancer de Montpellier (ICM), Montpellier, France.
Fabrizio PanaroDepartment of Surgery, St-Eloi University Hospital, Montpellier, France.
Lauranne PironDepartment of Radiology, St-Eloi University Hospital, Montpellier, France.
Christophe CassinottoDepartment of Radiology, St-Eloi University Hospital, Montpellier, France.
Astrid HerrerroDepartment of Surgery, St-Eloi University Hospital, Montpellier, France.
François-Régis SoucheDepartment of Surgery, St-Eloi University Hospital, Montpellier, France.
Margaux HermidaDepartment of Radiology, St-Eloi University Hospital, Montpellier, France.
Marie-Ange Pierredon-FoulongneDepartment of Radiology, St-Eloi University Hospital, Montpellier, France.
Ali BelgourDepartment of Radiology, St-Eloi University Hospital, Montpellier, France.
Serge Aho-GleleDepartment of Epidemiology, Dijon University Hospital, Dijon, France.
Emmanuel DeshayesDepartment of Nuclear Medicine, Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Montpellier, France.
Centre Hospitalier Universitaire de Montpellier · FRInserm · FRMaison des Sciences de l’Homme de Dijon · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe previously showed that embolization of portal inflow and hepatic vein (HV) outflow (liver venous deprivation, LVD) promotes future liver remnant (FLR) volume (FLR-V) and function (FLR-F) gain. Here, we compared FLR-V and FLR-F changes after portal vein embolization (PVE) and LVD.

methodsThis study included all patients referred for liver preparation before major hepatectomy over 26 months. Exclusion criteria were: unavailable baseline/follow-up imaging, cirrhosis, Klatskin tumor, two-stage hepatectomy. 99mTc-mebrofenin SPECT-CT was performed at baseline and at day 7, 14 and 21 after PVE or LVD. FLR-V and FLR-F variations were compared using multivariate generalized linear mixed models (joint modelling) with/without missing data imputation.

resultsBaseline FLR-F was lower in the LVD (n=29) than PVE group (n=22) (P<0.001). Technical success was 100% in both groups without any major complication. Changes in FLR-V at day 14 and 21 (+14.2%

conclusionsLVD is safe and provides greater FLR-V and FLR-F increase than PVE. These results are now evaluated in the HYPERLIV-01 multicenter randomized trial.

Indexed as

hepatectomyliver venous deprivation (LVD)mebrofeninPortal vein embolization (PVE)resection

Identifiers

PMID33163507
PMCPMC7603937
OpenAlexW3011999096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.