Evidence map›Paper›PMID 33163488›Full record

ArticleFrontiers in cell and developmental biology2020

Peroxisome Deficiency Impairs BDNF Signaling and Memory.

Yuichi Abe, Yoshiki Nishimura, Kaori Nakamura, Shigehiko Tamura, Masanori Honsho, Hiroshi Udo, Toshihide Yamashita, Yukio Fujiki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yuichi AbeDivision of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Yoshiki NishimuraGraduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.
Kaori NakamuraGraduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.
Shigehiko TamuraFaculty of Arts and Science, Kyushu University, Fukuoka, Japan.
Masanori HonshoInstitute of Rheological Functions of Food, Fukuoka, Japan.
Hiroshi UdoGraduate School of Systems Life Sciences, Kyushu University, Fukuoka, Japan.
Toshihide YamashitaDepartment of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Japan.
Yukio FujikiDivision of Organelle Homeostasis, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Kyushu University · JPInstitute of Rheological Functions of Food · JPOsaka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxisome is an intracellular organelle that functions in essential metabolic pathways including β-oxidation of very-long-chain fatty acids and biosynthesis of plasmalogens. Peroxisome biogenesis disorders (PBDs) manifest severe dysfunction in multiple organs including central nervous system (CNS), whilst the pathogenic mechanisms are largely unknown. We recently reported that peroxisome-deficient neural cells secrete an increased level of brain-derived neurotrophic factor (BDNF), resulting in the cerebellar malformation. Peroxisomal functions in adulthood brain have been little investigated. To induce the peroxisome deficiency in adulthood brain, we here established tamoxifen-inducible conditional

Indexed as

BDNFconditional knockoutmemory disturbanceneural stem cellperoxisomePex2TrkB

Identifiers

PMID33163488
PMCPMC7591468
OpenAlexW3093001702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.