Evidence map›Paper›PMID 33163350›Full record

ArticleActa pharmaceutica Sinica. B2020

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein.

Tingting Wang, Yingjie Guo, Yang He, Tianming Ren, Lei Yin, John Paul Fawcett, Jingkai Gu, Huimin Sun

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tingting WangClinical Laboratory, First Hospital, Jilin University, Changchun 130061, China.
Yingjie GuoResearch Center for Drug Metabolism, College of Life Science, Jilin University, Changchun 130012, China.
Yang HeDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City IA 52242, USA.
Tianming RenResearch Center for Drug Metabolism, College of Life Science, Jilin University, Changchun 130012, China.
Lei YinClinical Laboratory, First Hospital, Jilin University, Changchun 130061, China.
John Paul FawcettResearch Center for Drug Metabolism, College of Life Science, Jilin University, Changchun 130012, China.
Jingkai GuResearch Institute of Translational Medicine, First Hospital, Jilin University, Changchun 130061, China.
Huimin SunNational Institutes for Food and Drug Control, Beijing 100050, China.
Jilin University · CNNational Institutes for Food and Drug Control · CNUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyethylene glycols (PEGs) in general use are polydisperse molecules with molecular weight (MW) distributed around an average value applied in their designation

Indexed as

ACN, acetonitrileAUC, area under the plasma concentration-time curveCE, collision energyCmax, maximum plasma concentrationCsA, cyclosporine ADBD, drug-binding domainDDS, drug delivery systemDMEM, Dulbecco's modified Eagle's mediumDMSO, dimethyl sulfoxideDP, declustering potentialEndocytosisFBS, fetal bovine serumHBSS, Hanks' balanced salt solutionHEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidIS, internal standardLC−HRMS/MS, liquid chromatography−high resolution tandem mass spectrometryMW, molecular weightNBD, nucleotide binding domainPAC, paclitaxelPassive diffusionPEG, polyethylene glycolPEGsP-gpP-gp, P-glycoproteinP-gp-substrateVER, verapamil

Identifiers

PMID33163350
PMCPMC7606107
OpenAlexW3008345384

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.