Evidence map›Paper›PMID 33163338›Full record

ArticleActa pharmaceutica Sinica. B2020

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms.

Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W Somsen, Freek J Vonk, Nicholas R Casewell, Jeroen Kool

Open access · diamondAbstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Unraveling snake venom phospholipase APharmacological reports : PR · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Toxicon: X · 2022
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chunfang XieAmsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Julien SlagboomAmsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Laura-Oana AlbulescuCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
Govert W SomsenAmsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Freek J VonkAmsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Nicholas R CasewellCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.
Jeroen KoolAmsterdam Institute of Molecular and Life Sciences, Division of BioAnalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam 1081HV, The Netherlands.
Vrije Universiteit Amsterdam · NLLiverpool School of Tropical Medicine · GBNaturalis Biodiversity Center · NL

Funding

Medical Research Council MC_PC_18055Medical Research Council MR/S00016X/1Wellcome Trust 200517/Z/16/Z
6 · The paper itself

Abstract

Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific phospholipase A

Indexed as

ACN, acetonitrileAntivenomChelatorsCTL, C-type lectinsDimercaprolDMSO, dimethyl sulfoxideFA, formic acidHTS, high-throughput screeningLC, liquid chromatographyMarimastatMS, mass spectrometryNanofractionationNOI, no observed inhibitionPBS, phosphate buffered salinePLA2, phospholipase A2PN, partly neutralised at 20 μmol/L inhibitor concentrationsSnakebiteSVMP, snake venom metalloproteinaseSVSP, snake venom serine proteaseTIC, total ion currentVarespladibWHO, World Health OrganizationXIC, extracted ion current

Identifiers

PMID33163338
PMCPMC7606088
OpenAlexW3084899484

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.