Evidence map›Paper›PMID 33163277›Full record

ArticleAmerican journal of cancer research2020

Novel genetic variants of

Guiqing Lu, Bingrong Zhou, Yuanmin He, Hongliang Liu, Sheng Luo, Christopher I Amos, Jeffrey E Lee, Keming Yang, Abrar Qureshi, Jiali Han and 1 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guiqing LuDepartment of Dermatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University Nanjing 210019, Jiangsu, China.
Bingrong ZhouDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
Yuanmin HeDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
Hongliang LiuDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
Sheng LuoDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine Durham, NC 27710, USA.
Christopher I AmosInstitute for Clinical and Translational Research, Baylor College of Medicine Houston, TX 77030, USA.
Jeffrey E LeeDepartment of Surgical Oncology, The University of Texas M.D. Anderson Cancer Center Houston, TX 77030, USA.
Keming YangDepartment of Nutrition, Harvard T.H. Chan School of Public Health Boston, MA, USA.
Abrar QureshiDepartment of Dermatology, Warren Alpert Medical School, Brown University Providence, RI 02903, USA.
Jiali HanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital Boston, MA 02115, USA.
Qingyi WeiDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
UT M.D. Anderson Cancer Center SPORE in MelanomaP50CA093459 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GRIMM, ELIZABETH A · 2004 to 2014
$23.7M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Cancer Epidemiology Cohort in Male Health ProfessionalsU01CA167552 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Lorelei Mucci, Walter C. Willett · 2017 to 2026
$17.0M
BIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3M
Genetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5M
Statistical Methods for Gene Environment Interactions In Lung CancerR01CA133996 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I. · 2007 to 2009
$790k
NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA014236NCI NIH HHS P50 CA093459NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA100264NCI NIH HHS R01 CA133996NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Endosomes regulate cell polarity, adhesion, signaling, immunity, and tumor progression, which may influence cancer outcomes. Here we evaluated associations between 36,068 genetic variants of 228 endosome-related pathway genes and cutaneous melanoma disease-specific survival (CMSS) using genotyping data from two previously published genome-wide association studies. The discovery dataset included 858 CM patients with 95 deaths from The University of Texas MD Anderson Cancer Center, and the replication dataset included 409 CM patients with 48 deaths from the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). In multivariate Cox proportional hazards regression analysis, we found that two novel SNPs (

Indexed as

cutaneous melanoma-specific survivalendosome pathwayGenome-wide association studyimmunitysingle-nucleotide polymorphism

Identifiers

PMID33163277
PMCPMC7642651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.