Evidence map›Paper›PMID 33163269›Full record

ArticleAmerican journal of cancer research2020

Targeting the polycomb repressive complex-2 related proteins with novel combinational strategies for nasopharyngeal carcinoma.

Junyu Zhu, Lili Li, Joanna Tong, Connie Hui, Chi Hang Wong, Kwok Wai Lo, Raymond Chan, Qi Yong Ai, Edwin P Hui, Anthony Tc Chan and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Chromatin Control of EBV Infection and Latency.Current topics in microbiology and immunology · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Histone modifiers at the crossroads of oncolytic and oncogenic viruses.Molecular therapy : the journal of the American Society of Gene Therapy · 2022
    Review
  9. Nasopharyngeal carcinoma: an evolving paradigm.Nature reviews. Clinical oncology · 2021
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Junyu ZhuState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Lili LiState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Joanna TongDepartment of Anatomical and Cellular Pathology, The Prince of Wales Hospital Hong Kong, China.
Connie HuiState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Chi Hang WongState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Kwok Wai LoDepartment of Anatomical and Cellular Pathology, The Prince of Wales Hospital Hong Kong, China.
Raymond ChanState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Qi Yong AiDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong Hong Kong, China.
Edwin P HuiState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Anthony Tc ChanState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Ka F ToDepartment of Anatomical and Cellular Pathology, The Prince of Wales Hospital Hong Kong, China.
Qian TaoState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Brigette By MaState Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong, China.
Chinese University of Hong Kong · HKPrince of Wales Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant epigenetic regulation is critically involved in the pathogenesis of nasopharyngeal carcinoma (NPC), where abnormal histone methylation can be found in polycomb repressive complex-2 (PRC2) related cancer gene loci. This study investigated some novel combinational strategies against NPC

Indexed as

CDK4/6 inhibitorEED inhibitorEZH2 inhibitorMHC-Inasopharyngeal carcinoma

Identifiers

PMID33163269
PMCPMC7642668
OpenAlexW3106387357

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.