Evidence map›Paper›PMID 33163256›Full record

ArticleACS catalysis2020

Directed Evolution's Influence on Rapid Density Fluctuations Illustrates How Protein Dynamics Can Become Coupled to Chemistry.

Joseph W Schafer, Steven D Schwartz

Open access · greenAbstract read
In one paragraph

Article in ACS catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Predicting Activation Barriers With Ring and Bond Critical Points in the Kemp Elimination Reaction.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  2. Article
  3. Article
  4. Multifunctional nanomaterialsMaterials today. Bio · 2024
    Article
  5. Article
  6. Article
  7. Protein Dynamics and Enzymatic Catalysis.The journal of physical chemistry. B · 2023
    Review
  8. Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  9. Article
  10. Review
  11. Perspective: Path Sampling Methods Applied to Enzymatic Catalysis.Journal of chemical theory and computation · 2022
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joseph W SchaferDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.
Steven D SchwartzDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721, United States.ORCID 0000-0002-0308-1059
University of Arizona · US

Funding

Rapid protein dynamics and catalysis: modulation by laboratory evolution, designed mutation, and protein control of electric field environmentR01GM127594 · NIGMS · UNIVERSITY OF ARIZONA · PI SCHWARTZ, STEVEN D · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM127594
6 · The paper itself

Abstract

Protein engineering is a growing field with a variety of experimental techniques available for altering protein function. However, creating an enzyme

Indexed as

directed evolutionhydrogen bonding networkMarkov chain Monte Carloprotein dynamicsQMMM simulationtransition path sampling

Identifiers

PMID33163256
PMCPMC7643869
OpenAlexW3041034246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.