Evidence map›Paper›PMID 33163246›Full record

ArticleImmune network2020

Lactoferrin Induces Tolerogenic Bone Marrow-Derived Dendritic Cells.

Hui-Won Park, Sun-Hee Park, Hyeon-Ju Jo, Tae-Gyu Kim, Jeong Hyun Lee, Seung-Goo Kang, Young-Saeng Jang, Pyeung-Hyeun Kim

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immune network, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hui-Won ParkDepartment of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon, Korea.
Sun-Hee ParkDepartment of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon, Korea.
Hyeon-Ju JoDepartment of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon, Korea.
Tae-Gyu KimDepartment of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon, Korea.
Jeong Hyun LeeDepartment of Systems Immunology, School of Biomedical Science, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-2801-3677
Seung-Goo KangDepartment of Systems Immunology, School of Biomedical Science, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-3981-1399
Young-Saeng JangInstitute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0001-9844-2074
Pyeung-Hyeun KimInstitute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Korea.ORCID https://orcid.org/0000-0002-2808-5822
Kangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that initiate both T-cell responses and tolerance. Tolerogenic DCs (tDCs) are regulatory DCs that suppress immune responses through the induction of T-cell anergy and Tregs. Because lactoferrin (LF) was demonstrated to induce functional Tregs and has a protective effect against inflammatory bowel disease, we explored the tolerogenic effects of LF on mouse bone marrow-derived DCs (BMDCs). The expression of CD80/86 and MHC class II was diminished in LF-treated BMDCs (LF-BMDCs). LF facilitated BMDCs to suppress proliferation and elevate Foxp3

Indexed as

B7 antigensDendritic cellsImmune toleranceLactoferrinRegulatory T cellsSuppressive factor

Identifiers

PMID33163246
PMCPMC7609161
OpenAlexW3095937852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.