Evidence map›Paper›PMID 33163023›Full record

ArticleAfrican health sciences2020

Adherence to the MDR-TB intensive phase treatment protocol amongst individuals followed up at central and peripheral health care facilities in Uganda - a descriptive study.

Joseph Mukasa, Edward Kayongo, Ismael Kawooya, Deus Lukoye, Alfred Etwom, Frank Mugabe, Hannock Tweya, Rose Izizinga, Rhona Mijumbi-Deve

Open access · diamondAbstract read
In one paragraph

Article in African health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Joseph MukasaRegional Tuberculosis and Leprosy Supervisory Office, East and Central Uganda, P. O. Box 217, Iganga, Uganda.
Edward KayongoThe Center for Rapid Evidence Synthesis (ACRES), Makerere University College of Health Sciences, Kampala, Uganda.
Ismael KawooyaThe Center for Rapid Evidence Synthesis (ACRES), Makerere University College of Health Sciences, Kampala, Uganda.
Deus LukoyeManagement Sciences for Health, Princess Ann drive, Bugolobi, Kampala, Uganda.
Alfred EtwomNational TB and Leprosy Control Program, Ministry of Health, Plot 6, Lourdel Road, Nakasero, Kampala, Uganda.
Frank MugabeNational TB and Leprosy Control Program, Ministry of Health, Plot 6, Lourdel Road, Nakasero, Kampala, Uganda.
Hannock TweyaThe International Union Against Tuberculosis and Lung Disease, Paris, France.
Rose IzizingaThe Center for Rapid Evidence Synthesis (ACRES), Makerere University College of Health Sciences, Kampala, Uganda.
Rhona Mijumbi-DeveThe Center for Rapid Evidence Synthesis (ACRES), Makerere University College of Health Sciences, Kampala, Uganda.
Makerere University · UGMinistry of Health · UGInternational Union Against Tuberculosis and Lung Disease · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFollowing initiation of MDR-TB treatment, patients have a choice to receive follow up DOT supervision at either the central initiating facility or at a peripheral facility.

objectivesWe describe the adherence patterns of MDR-TB patients undergoing DOT supervision at the two health facility categories during intensive phase of treatment.

methodsWe used a retrospective cohort of patients initiated on MDR TB treatment at Mulago National Referral Hospital between 2014 and 2016. We extracted data from the National Tuberculosis and Leprosy Program records and analysed these using STATA V14.

resultMajority (84.01%) of the patients received their DOT supervision from the peripheral facilities. Males made up 62.1% of patients, and 91.2% had had their household contacts screened for MDR-TB. 26.5% of the patients on peripheral DOT supervision had good adherence to treatment protocol compared to 0% among patients on central initiating health facility DOT supervision. Among the patients with good adherence, 24.1% had contacts screened for MDR-TB as compared to 3.6% with poor adherence.

conclusionMore patients preferred MDR-TB DOT supervision at peripheral facilities, which had better adherence to the treatment protocol compared to the central initiating facility. Younger people and those with household contacts screened had better adherence to the treatment protocol, highlighting areas for targeted interventional programs for MDR-TB in resource limited settingsMore patients preferred MDR-TB DOT supervision at peripheral facilities, which had better adherence to the treatment protocol compared to the central initiating facility. Younger people and those with household contacts screened had better adherence to the treatment protocol, highlighting areas for targeted interventional programs for MDR-TB in resource limited settings.

Indexed as

Drug MonitoringAdolescentAdultAntitubercular AgentsCohort StudiesContact TracingFemaleFollow-Up StudiesHealth FacilitiesHumansMaleRetrospective StudiesTreatment OutcomeTuberculosisTuberculosis, Multidrug-ResistantUgandaAntitubercular Agentsadherencecentral initiatingDOTSMDR-TBperipheral health facilitySORT IT

Identifiers

PMID33163023
PMCPMC7609083
OpenAlexW3044247718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.