Evidence map›Paper›PMID 33162974›Full record

ArticleFrontiers in immunology2020

Nathalia Benavides, Waldo A Spessott, Maria L Sanmillan, Marcelo Vargas, Mylynda S Livingston, Nissa Erickson, Tamara C Pozos, Margaret E McCormick, Emilia Scharrig, Yoav H Messinger and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nathalia BenavidesDepartment of Microbiology and Immunology- Sydney Kimmel Medical College- Thomas Jefferson University, Philadelphia, PA, United States.
Waldo A SpessottDepartment of Microbiology and Immunology- Sydney Kimmel Medical College- Thomas Jefferson University, Philadelphia, PA, United States.
Maria L SanmillanDepartment of Microbiology and Immunology- Sydney Kimmel Medical College- Thomas Jefferson University, Philadelphia, PA, United States.
Marcelo VargasDepartment of Medical Genetics and Genomics, Children's Minnesota, Minneapolis, MN, United States.
Mylynda S LivingstonDepartment of Pediatric Hematology-Oncology, Children's Minnesota, Minneapolis, MN, United States.
Nissa EricksonMinnesota Gastroenterology, P.A., Minneapolis, MN, United States.
Tamara C PozosDepartment of Immunology, Children's Minnesota, Minneapolis, MN, United States.
Margaret E McCormickDepartment of Microbiology and Immunology- Sydney Kimmel Medical College- Thomas Jefferson University, Philadelphia, PA, United States.
Emilia ScharrigDepartment of Microbiology and Immunology- Sydney Kimmel Medical College- Thomas Jefferson University, Philadelphia, PA, United States.
Yoav H MessingerDepartment of Pediatric Hematology-Oncology, Children's Minnesota, Minneapolis, MN, United States.
Claudio G GiraudoDepartment of Microbiology and Immunology- Sydney Kimmel Medical College- Thomas Jefferson University, Philadelphia, PA, United States.
Thomas Jefferson University · USChildren's Minnesota · USMinnesota Gastroenterology · US

Funding

Role of Stx11 and STXBP2 in lytic granule exocytosis in health and diseaseR01AI123538 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI GIRAUDO, CLAUDIO GUILLERMO · 2017 to 2021
$2.1M
Exocytosis of Lytic granulesR01GM123020 · NIGMS · THOMAS JEFFERSON UNIVERSITY · PI GIRAUDO, CLAUDIO GUILLERMO · 2017 to 2021
$1.6M
Training grant on Vaccines and Immunotherapies for Infectious Diseases and CancerT32AI134646 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SCHNELL, MATTHIAS JOHANNES, SIGAL, LUIS J · 2018 to 2022
$1.1M
NIAID NIH HHS R01 AI123538NIAID NIH HHS T32 AI134646NIGMS NIH HHS R01 GM123020
6 · The paper itself

Abstract

Neonatal hemophagocytic lymphohistiocytosis (HLH) is a medical emergency that can be associated with significant morbidity and mortality. Often these patients present with familial HLH (f-HLH), which is caused by gene mutations interfering with the cytolytic pathway of cytotoxic T-lymphocytes (CTLs) and natural killer cells. Here we describe a male newborn who met the HLH diagnostic criteria, presented with profound cholestasis, and carried a maternally inherited heterozygous mutation in

Indexed as

MutationAllelesAmino Acid SequenceAmino Acid SubstitutionApoptosisBiomarkersCytotoxicity, ImmunologicDisease SusceptibilityExocytosisGene ExpressionGenetic Association StudiesGlucosephosphate Dehydrogenase DeficiencyHumansInfant, NewbornKiller Cells, NaturalLymphohistiocytosis, HemophagocyticBiomarkersMembrane ProteinsMunc18 ProteinsQa-SNARE ProteinsSTX11 protein, humanSTXBP2 protein, humanUNC13D protein, humancytotoxic T-lymphocytes (CTLs)familial hemophagocytic lymphohistiocytosis−5 (f-HLH)G6PD deficiencylytic granule exocytosisnatural killer cellsSNAREsSTXBP2

Identifiers

PMID33162974
PMCPMC7580532
OpenAlexW3092511716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.