Evidence map›Paper›PMID 33162889›Full record

ArticleFrontiers in pharmacology2020

Fecal Microbial Signatures Are Associated With Engraftment Failure Following Umbilical Cord Blood Transplantation in Pediatric Crohn's Disease Patients With

Aijuan Xue, Xiaowen Qian, Xuefeng Gao, Ping Wang, Lin Wang, Cuifang Zheng, Zhiheng Huang, Wenhui Hu, Jieru Shi, Ying Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Aijuan XueDepartment of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Xiaowen QianDepartment of Hematology, Children's Hospital of Fudan University, Shanghai, China.
Xuefeng GaoDepartment of Hematology-Oncology, International Cancer Center, Shenzhen University General Hospital, Shenzhen University Health Science Center, Shenzhen, China.
Ping WangDepartment of Hematology, Children's Hospital of Fudan University, Shanghai, China.
Lin WangDepartment of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Cuifang ZhengDepartment of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Zhiheng HuangDepartment of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Wenhui HuDepartment of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Jieru ShiDepartment of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Ying HuangDepartment of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CNShenzhen University Health Science Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesUmbilical cord blood transplantation (UCBT) is associated with a relatively high rate of engraftment failure. This study aimed at exploring whether any fecal microbiota could be associated with engraftment failure following UCBT in Crohn's disease patients with

methodsThirteen patients were recruited and their 230 fecal samples were collected longitudinally from immediately before conditioning chemotherapy to 8 weeks post the UCBT. The V3-V4 regions of the bacterial 16S rRNA gene were amplified by PCR and sequenced, followed by bioinformatics analyses.

resultsFollowing the UCBT, 7 out of 13 patients achieved neutrophil and platelet engraftment with a median of 21 and 28 days, respectively (S group), while 6 patients failed to achieve engraftment (F group). In comparison with that in the S group, significantly lower Shannon diversity values on the UCBT day (

conclusionsMicrobial indicators of reduced diversity of microbiota and signatures of specific bacterial abundances, such as a lower abundance of

Indexed as

Crohn’s diseaseIL10RAmicrobiomepediatricumbilical cord blood transplantation

Identifiers

PMID33162889
PMCPMC7580494
OpenAlexW3091880010

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.