ArticleFrontiers in neuroscience2020
Systematic Evaluation of DBS Parameters in the Hemi-Parkinsonian Rat Model.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Cortical and basal ganglia beta oscillations and frequency-dependent DBS effects in the A53T Parkinson's disease rat model.NPJ Parkinson's disease · 2026Article
- A longitudinal electrophysiological and behavior dataset for PD rat in response to deep brain stimulation.Scientific data · 2024Article
- Subthalamic nucleus deep brain stimulation alleviates oxidative stress via mitophagy in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Nonlinear analysis of neuronal firing modulated by sinusoidal stimulation at axons in rat hippocampus.Frontiers in computational neuroscience · 2024Article
- Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson's Patients: Neuroinflammation and Pyroptosis.Current issues in molecular biology · 2023Review
- Deep brain stimulation for movement disorder treatment: exploring frequency-dependent efficacy in a computational network model.Biological cybernetics · 2022Article
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3 authors at 1 institution in 1 country.
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Abstract
Electrical stimulation of the subthalamic nucleus (STN) is clinically employed to ameliorate several symptoms of manifest Parkinson's Disease (PD). Stimulation parameters utilized by chronically implanted pulse generators comprise biphasic rectangular short (60-100 μs) pulses with a repetition frequency between 130 and 180 Hz. A better insight into the effect of electrical stimulation parameters could potentially reveal new possibilities for the improvement of deep brain stimulation (DBS) as a treatment. To this end, we employed single-sided 6-hydroxidopamine (6-OHDA) lesioning of the medial forebrain bundle (MFB) in rats to systematically investigate alternative stimulation parameters. These hemi-parkinsonian (hemi-PD) rats underwent individualized, ipsilateral electrical stimulation to the STN of the lesioned hemisphere, while the transiently induced contralateral rotational behavior was quantified to assess the effect of DBS parameter variations. The number of induced rotations during 30 s of stimulation was strongly correlated with the amplitude of the stimulation pulses. Despite a general linear relation between DBS frequency and rotational characteristics, a plateau effect was observed in the rotation count throughout the clinically used frequency range. Alternative waveforms to the conventional biphasic rectangular (
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