Evidence map›Paper›PMID 33162801›Full record

Observational studyInternational journal of medical sciences2020

Geniposide inhibits proliferation and induces apoptosis of diffuse large B-cell lymphoma cells by inactivating the HCP5/miR-27b-3p/MET axis.

Linjun Hu, Junjun Zhao, Yang Liu, Xin Liu, Qiliang Lu, Zhi Zeng, Lifen Zhu, Xiangmin Tong, Qiuran Xu

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in International journal of medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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  17. Sendeng-4 Suppressed Melanoma Growth by Induction of Autophagy and Apoptosis.Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Linjun HuThe Medical College of Qingdao University, Qingdao, Shandong 266071, China.
Junjun ZhaoGraduate Department, BengBu Medical College, BengBu, Anhui 233030, China.
Yang LiuThe Medical College of Qingdao University, Qingdao, Shandong 266071, China.
Xin LiuKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.
Qiliang LuThe Medical College of Qingdao University, Qingdao, Shandong 266071, China.
Zhi ZengThe Medical College of Qingdao University, Qingdao, Shandong 266071, China.
Lifen ZhuKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.
Xiangmin TongKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.
Qiuran XuKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, Zhejiang 310014, China.
Hangzhou Medical College · CNQingdao University · CNZhejiang Provincial People's Hospital · CNBengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is commonly treated with R-CHOP, but ~30 to 50% of the patients are poorly responsive to this strategy. Geniposide, an extract from the

Indexed as

ApoptosisCase-Control StudiesCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorGene Expression Regulation, NeoplasticGene Knockdown TechniquesGene SilencingHumansIridoidsLymph NodesLymphoma, Large B-Cell, DiffuseMicroRNAsProto-Oncogene Proteins c-metRNA, Long NoncodingSignal TransductiongeniposideHCP5 long noncoding RNA, humanIridoidsMET protein, humanMicroRNAsMIRN27 microRNA, humanProto-Oncogene Proteins c-metRNA, Long Noncodingapoptosiscell proliferationDLBCLGeniposideHCP5METmiR-27b-3p

Identifiers

PMID33162801
PMCPMC7645330
OpenAlexW3092458714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.