Evidence map›Paper›PMID 33162767›Full record

ReviewDialogues in clinical neuroscience2020

Cannabinoids and the endocannabinoid system in reward processing and addiction: from mechanisms to interventions
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Rainer Spanagel

Registry-linked trialOpen access · diamondAbstract readReview
In one paragraph

Review in Dialogues in clinical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06218056 (Evaluating the Efficacy of Cannabidiol for Reducing Cigarette Use), which is not on this map. Cited by 56 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06218056 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluating the Efficacy of Cannabidiol for Reducing Cigarette Use

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2026Enrolled120ConditionsTobacco Use Disorder, Tobacco Smoking, Tobacco DependenceArmsCannabidiol (CBD) 800 mg, Placebo
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 116 citations in OpenAlex.

  1. Pooled it
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  13. Exploring the interaction between cannabis and music.Annals of the New York Academy of Sciences · 2025
    Article
  14. Cue-induced Magnetic Resonance Spectroscopy of Glutamate in Addiction Research: Current Evidence, Pros, and Cons.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Rainer SpanagelInstitute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Germany.
Central Institute of Mental Health · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The last decades have seen a major gain in understanding the action of cannabinoids and the endocannabinoid system in reward processing and the development of addictive behavior. Cannabis-derived psychoactive compounds such as Δ

Indexed as

RewardAnimalsBehavior, AddictiveCannabinoidsDrug-Seeking BehaviorEndocannabinoidsHumansMarijuana AbuseReceptors, CannabinoidCannabinoidsEndocannabinoidsReceptors, CannabinoidaddictionalcoholcannabinoidCB1/CB2-receptor blockadecocainecravingdrug rewardendocannabinoid systemheroinnatural rewardnicotinephasic dopaminereward systemsubstitution therapytonic dopamine

Identifiers

PMID33162767
PMCPMC7605022
OpenAlexW3105701481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.