Evidence map›Paper›PMID 33162483›Full record

ArticleInternal medicine (Tokyo, Japan)2021

Early Pathological JC Virus Lesions in a Patient without Any MRI-based Indications.

Nobuo Sanjo, Yurie Nose, Shouhei Miyamoto, Yukiko Shishido-Hara, Tatsuya Saito, Tetsuya Fukuda, Kurara Yamamoto, Daisuke Kobayashi, Takanori Yokota

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nobuo SanjoDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.
Yurie NoseDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.
Shouhei MiyamotoDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.
Yukiko Shishido-HaraDepartment of Anatomic Pathology, Tokyo Medical University, Japan.
Tatsuya SaitoDepartment of Hematology, Tokyo Medical and Dental University, Japan.
Tetsuya FukudaDepartment of Hematology, Tokyo Medical and Dental University, Japan.
Kurara YamamotoDepartment of Human Pathology, Tokyo Medical and Dental University, Japan.
Daisuke KobayashiDepartment of Human Pathology, Tokyo Medical and Dental University, Japan.
Takanori YokotaDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.
Tokyo Medical and Dental University · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 70-year-old woman with a human T-cell leukemia virus type 1 infection without any focal neurological symptoms showed age-related atherosclerotic changes in the white matter without any suspicious signal changes suggestive of progressive multifocal leukoencephalopathy (PML) based on the findings of MRI. Viral polymerase chain reaction (PCR) revealed 6,700 copies/mL of the JC virus genome in the cerebrospinal fluid (CSF). An immuno-pathological examination of the autopsied brain revealed JC virus capsid proteins, and in situ hybridization confirmed a JC virus infection, indicating that an active infection begins at the radiologically indistinguishable phase of PML. An early JC virus infection is probably associated with small, scattered demyelinating lesions around the cortico-medullary area of the cortex.

Indexed as

JC VirusLeukoencephalopathy, Progressive MultifocalAgedBrainDNA, ViralFemaleHumansMagnetic Resonance ImagingDNA, ViralCSF PCRJC virusprogressive multifocal leukoencephalopathyviral infection

Identifiers

PMID33162483
PMCPMC8112995
OpenAlexW3105221324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.