ReviewAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2021
Cell Analysis on Microfluidics Combined with Mass Spectrometry.
Review in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- A modular potentiometric sensor platform with detachable microfluidics for multiplexed analysis of low-volume biofluids.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Advances in microfluidic chip technology for cell analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- Pollution-Free and Highly Sensitive Lactate Detection in Cell Culture Based on a Microfluidic Chip.Micromachines · 2023Article
- Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry.Journal of pharmaceutical analysis · 2023Article
- Recent advances of integrated microfluidic suspension cell culture system.Engineering biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell analysis is of great significance for the exploration of human diseases and health. However, there are not many techniques for high-throughput cell analysis in the simulated cell microenvironment. The high designability of the microfluidic chip enables multiple kinds of cells to be co-cultured on the chip, with other functions such as sample preprocessing and cell manipulation. Mass spectrometry (MS) can detect a large number of biomolecules without labelling. Therefore, the application of the microfluidic chip coupled with MS has represented a major branch of cell analysis over the past decades. Here, we concisely introduce various microfluidic devices coupled with MS used for cell analysis. The main functions of microfluidic devices are described first, followed by introductions of different interfaces with different types of MS. Then, their various applications in cell analysis are highlighted, with an emphasis on cell metabolism, drug screening, and signal transduction. Current limitations and prospective trends of microfluidics coupled with MS are discussed at the end.
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Registered trials
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