Evidence map›Paper›PMID 33162013›Full record

ArticleInjury2021

Cost-Effectiveness analysis of the surgical management of fractures in Malawi: An economic evaluation of a high and low-income country surgical collaboration.

Chidera Agwu, Laura N Purcell, Jared Gallaher, Sven Young, Leonard Banza, Alyssa J Mansfield, Anthony Charles

Open access · greenAbstract read
In one paragraph

Article in Injury, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Improving the management of open tibia fractures, Malawi.Bulletin of the World Health Organization · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Chidera AgwuUniversity of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Health Policy and Management.
Laura N PurcellUniversity of North Carolina at Chapel Hill, School of Medicine, Department of Surgery, 4008 Burnett Womack Building, CB 7228, United States.
Jared GallaherUniversity of North Carolina at Chapel Hill, School of Medicine, Department of Surgery, 4008 Burnett Womack Building, CB 7228, United States.
Sven YoungDepartment of Orthopedics, Haukeland University, Bergen, Norway.
Leonard BanzaDepartment of Surgery, Kamuzu Central Hospital, Malawi.
Alyssa J MansfieldUniversity of North Carolina at Chapel Hill, Gillings School of Global Public Health, Department of Health Policy and Management.
Anthony CharlesUniversity of North Carolina at Chapel Hill, School of Medicine, Department of Surgery, 4008 Burnett Womack Building, CB 7228, United States. Electronic address: anthchar@med.unc.edu.
University of North Carolina at Chapel Hill · USHaukeland University Hospital · NOKamuzu Central Hospital · MW

Funding

UJMT – ORWH – Gazzetta, Issa-BoubeD43TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William Checkley, Benjamin H. Chi · 2017 to 2026
$14.8M
TRAUMA RESEARCH FELLOWSHIPT32GM008450 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bruce A Cairns, Anthony G Charles · 1992 to 2026
$3.8M
FIC NIH HHS D43 TW009340NIGMS NIH HHS T32 GM008450
6 · The paper itself

Abstract

introductionCost-effectiveness is an essential tool for identifying high-value interventions in resource-limited settings. This study aims to evaluate the cost-effectiveness of the surgical management of fractures by surgical residents at Kamuzu Central Hospital (KCH). Currently, the 5-year surgical training program is supported by the Malawi Ministry of Health, and two universities in the United States and Norway.

methodsWe performed a modeled cost-effectiveness analysis (CEA) from a public health sector perspective. Cost data were collected from the current residency program and effectiveness data estimated from clinical data derived from operative interventions for fractures between 2013 and 2017 at KCH. Three patient groups were used as the base case; (1) patients of all ages, (2) patients age ≥18 years, and (3) patients who were <18 years. A Monte Carlo simulation of 10,000 trials was conducted for the probabilistic sensitivity analysis.

resultsThe estimated average lifetime cost of training and compensating residency-trained surgeons over a 35-year career was $448,600 (SD $31,167). The incremental cost-effectiveness ratio (ICER) for providing surgical care to patients of all ages was $215 (SD $3,666) per disability-adjusted life-year (DALY), which is below the willingness-to pay-threshold (WTP) of $1,170 per DALY and highly cost-effective at a WTP threshold of $390. Each surgeon is estimated to avert approximately 5,570 DALYs during their career when performing operations to treat fractures.

conclusionThe KCH surgical training program is highly cost-effective at reducing disability at an incremental cost of $215 per averted DALY. This CEA demonstrates that the current surgical training program is cost-effective in reducing morbidity among individuals with fractures.

Indexed as

Fractures, BoneAdolescentCost-Benefit AnalysisHumansMalawiNorwayQuality-Adjusted Life Years

Identifiers

PMID33162013
PMCPMC8084876
OpenAlexW3095317278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.