ArticleLipids in health and disease2020
Association between triglyceride-glucose index and risk of incident diabetes: a secondary analysis based on a Chinese cohort study : TyG index and incident diabetes.
Article in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 65 papers, 3 of them syntheses that pooled it.
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Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.
- Association between triglyceride glucose index and atrial fibrillation: A systematic review and meta-analysis.Asia Pacific journal of clinical nutrition · 2025Pooled it
- Hypertriglyceridemia is a dose-dependent risk factor for type 2 diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Pooled it
- Integrated Cardio-Renal-Metabolic Risk Profiling in Patients with Type 2 Diabetes: A Machine Learning-Assisted Cross-Sectional Analysis.Journal of clinical medicine · 2026Article
- Joint association of TyG-ABSI composite index and inflammatory score with diabetes in middle-aged and older Chinese adults: a prospective cohort study from CHARLS (2011-2020).BMC endocrine disorders · 2026Article
- Association between triglyceride glucose-body roundness index and incidence diabetes mellitus: a cohort study.Metabolism open · 2026Article
- Nonlinear associations between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes risk in Chinese prediabetic adults: a cohort study.Scientific reports · 2026Article
- Association between the triglyceride-glucose index and risk of type 2 diabetes mellitus and the mediating effect of BMI: a comparative analysis in Chinese and Japanese populations.Frontiers in endocrinology · 2026Article
- Predictive performance of cardiometabolic indices for prediabetes progression to diabetes and reversion to normoglycemia in adults: a cohort study.Frontiers in nutrition · 2026Article
- Association of the TyG-GGT index, a novel insulin resistance marker, with incident diabetes mellitus: a large-scale retrospective cohort study.Frontiers in endocrinology · 2026Article
- The association between triglyceride-glucose index with gestational diabetes mellitus in pregnant women: a cohort study among Chinese women.Frontiers in medicine · 2026Article
- Joint association of triglyceride-glucose index and Chinese visceral adiposity index with prevalent diabetes: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Cross-sectional associations of metabolic risk indices and cardiometabolic multimorbidity among adults with depressive symptoms: evidence from China and the United Kingdom.Archives of medical science : AMS · 2026Article
- Association of the triglyceride-glucose index/high-density lipoprotein cholesterol ratio, a novel insulin resistance marker, with incident diabetes mellitus: a large-scale retrospective cohort study.Frontiers in endocrinology · 2026Article
- Longitudinal trajectories of the triglyceride-glucose index and risk of incident type 2 diabetes in adults undergoing repeated health examinations.Frontiers in endocrinology · 2026Article
- Association of TyG-related indices with incident DM among NAFLD patients: a retrospective study.Hormones (Athens, Greece) · 2025Article
- High triglyceride-glucose index is associated with diabetes mellitus in people with HIV in Southwest China.AIDS (London, England) · 2025Article
- Age Stratified Analyses of TyG Index eGDR and Additive Effects on T2DM Outcomes in Prevalence and Mortality.Scientific reports · 2025Article
- Triglyceride-glucose (TyG) index combined with C-reactive protein outperforms the TyG index alone in predicting stroke in arthritis patients: a nationwide prospective cohort study.Lipids in health and disease · 2025Article
- Triglyceride-Glucose Index and New-Onset Type 2 Diabetes Mellitus in Middle-Aged Men.Metabolites · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRecent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults.
methodsThis retrospective cohort study was conducted using data from the health screening program in China. A total of 201,298 non-diabetic individuals were included. TyG index was calculated as Ln [fasting plasma glucose (mg/dL) × fasting triglyceride level (mg/dL) / 2]. Diabetes was defined as fasting plasma glucose ≥126 mg/dL and/or self-reported diabetes. Cox proportion-hazard model was employed to evaluate the independent impact of baseline TyG index on future diabetes risk. Sensitivity and subgroup analyses were implemented to verify the reliability of results. Notably, data were downloaded from the DATADRYAD website, and used only for secondary analyses.
resultsDuring an average follow-up of 3.12 years, among 201,298 individuals aged ≥20 years, 3389 subjects developed diabetes. After adjusting for potential confounders, elevated TyG index were independently correlated with greater risk of incident diabetes (hazard ratio (HR), 3.34; 95% confidence interval (CI), 3.11-3.60). Compared with the lowest quartile (Q1), increasing TyG index (Q2, Q3, and Q4) was related to increased HR estimates of incident diabetes [HR (95% CI), 1.83 (1.49-2.26); 3.29 (2.70-4.01), and 6.26 (5.15-7.60), respectively]. Moreover, a nonlinear relationship was observed between TyG index and risk of diabetes and the slope of the curve increased accompanying the rise of TyG index. Subgroup analysis revealed the positive association was stronger among subjects with age < 40 years, body mass index ≥18.5 kg/m
conclusionsElevated TyG index is independently correlated with increased risk of incident diabetes in Chinese adults, indicating it may represent a reliable predictor of diabetes in high-risk populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.