Evidence map›Paper›PMID 33161885›Full record

SynthesisThyroid : official journal of the American Thyroid Association2021

Clinical Outcomes After Discontinuation of Thyroid Hormone Replacement: A Systematic Review and Meta-Analysis.

Nydia Burgos, Freddy J K Toloza, Naykky M Singh Ospina, Juan P Brito, Ramzi G Salloum, Leslie C Hassett, Spyridoula Maraka

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Thyroid : official journal of the American Thyroid Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04288115 (Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism), which is not on this map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04288115 phase4completednot on this map

Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism: a Pilot Randomized, Double-blinded, Placebo-controlled Study

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2021 to 2022Enrolled52ConditionsSubclinical HypothyroidismArmsLevothyroxine, Placebo
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Approach to the Patient Considering Thyroid Hormone Deprescribing.The Journal of clinical endocrinology and metabolism · 2026
    Review
  6. A Qualitative Study of Clinician Barriers and Facilitators to De-escalation of Thyroid Stimulating Hormone Suppression in Thyroid Cancer Survivors.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Considerations in the Diagnosis and Management of Thyroid Dysfunction in Older Adults.Thyroid : official journal of the American Thyroid Association · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Nydia BurgosDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
Freddy J K TolozaDivision of Endocrinology and Metabolism, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Naykky M Singh OspinaKnowledge and Evaluation Research Unit, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Juan P BritoKnowledge and Evaluation Research Unit, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Ramzi G SalloumDepartment of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida, USA.
Leslie C HassettMayo Clinic Libraries, Mayo Clinic, Rochester, Minnesota, USA.
Spyridoula MarakaDivision of Endocrinology and Metabolism, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
University of Arkansas Medical Center · USUniversity of Florida · USMayo Clinic · USMayo Clinic in Florida · USUniversity of Puerto Rico, Medical Sciences Campus · PR

Funding

Adequate selection of patients for thyroid biopsy: evaluation of a shared decision making conversation aidK08CA248972 · NCI · UNIVERSITY OF FLORIDA · PI SINGH OSPINA, NAYKKY · 2020 to 2024
$1.1M
NCI NIH HHS K08 CA248972
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Asymptomatic DiseasesDeprescriptionsHormone Replacement TherapyHumansHypothyroidismThyroxineThyroxinedeprescribinglevothyroxinemedication withdrawalsubclinical hypothyroidismthyroid dysfunction

Identifiers

PMID33161885
PMCPMC8110016
OpenAlexW3100547195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.