Evidence map›Paper›PMID 33161737›Full record

Trial reportBeneficial microbes2020

R E Trotter, A R Vazquez, D S Grubb, K E Freedman, L E Grabos, S Jones, C L Gentile, C L Melby, S A Johnson, T L Weir

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Beneficial microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05750433 (PHAGE 3), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05750433 nacompletednot on this mapstarted 2021, after this paper: background citation

PHAGE 3: Determination of Phage and Probiotic Synergistic Effects on Gastrointestinal Health

TypeinterventionalSponsorColorado State UniversityRan2021 to 2024Enrolled120ConditionsGastrointestinal DysfunctionArmsPreforPro+B. subtilis DE111 probiotics, Placebo, B. subtilis DE111
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. The probioticGut microbes
    Trial
  5. Review
  6. Oral Supplementation ofDentistry journal · 2026
    Article
  7. Article
  8. Functional Evaluation ofFoods (Basel, Switzerland) · 2025
    Article
  9. Review
  10. Article
  11. Review
  12. A taste of one's own medicine:Frontiers in immunology · 2025
    Article
  13. Secondary Metabolites fromCurrent research in microbial sciences · 2025
    Review
  14. Article
  15. Review
  16. The gut microbiome as a modulator of arterial function and age-related arterial dysfunction.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  17. Review
  18. Preclinical Safety Assessment ofMicroorganisms · 2022
    Article
  19. The Impact of ProbioticAnimals : an open access journal from MDPI · 2022
    Review
  20. Frontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

R E TrotterDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
A R VazquezDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
D S GrubbDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
K E FreedmanDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
L E GrabosDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
S JonesDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
C L GentileDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
C L MelbyDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
S A JohnsonDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
T L WeirDepartment of Food Science and Human Nutrition, Colorado State University, 502 W Lake St, Fort Collins, CO 80523-1571, USA.
Colorado State University · US

Funding

The Obese Microbiota as a Novel Regulator of Vascular Function: A Translational ApproachR01HL144611 · NHLBI · COLORADO STATE UNIVERSITY · PI GENTILE, CHRISTOPHER L, WEIR, TIFFANY L · 2019 to 2022
$1.4M
NHLBI NIH HHS R01 HL144611
6 · The paper itself

Abstract

Cardiovascular disease (CVD) is the leading cause of death in the US and worldwide. By 2030 it is anticipated that CVD will claim the lives of more than 24 million people. Throughout the last decade, researchers have investigated the role of the gut microbiota in the development of CVD. Evidence exists for a positive correlation between

Indexed as

AdolescentAdultAgedBacillus subtilisCholesterolCholesterol, LDLDouble-Blind MethodFemaleHemodynamicsHumansLipidsMaleMiddle AgedProbioticsYoung AdultCholesterolCholesterol, LDLLipidsBacillus subtilisbacteriophageBifidobacterium lactiscardiovascular diseaseprobioticvascular function

Identifiers

PMID33161737
PMCPMC8773468
OpenAlexW3100858819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.