Trial reportTechniques in coloproctology2021
Prophylactic negative-pressure wound therapy after ileostomy reversal for the prevention of wound healing complications in colorectal cancer patients: a randomized controlled trial.
Trial report in Techniques in coloproctology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04088162 (The Use of Post-operative Negative Pressure Wound Therapy), which is not on this map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Use of Post-operative Negative Pressure Wound Therapy (NPWT) Dressing in the Prevention of Wound Healing Problems and Infectious Complications After Ostomy Reversal Surgery.
Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Pooled it
- Negative-pressure wound therapy in thoracic and abdominal surgery: meta-analysis of randomized trials.BJS open · 2026Pooled it
- The use of negative pressure wound therapy following stoma reversal: a systematic review and meta-analysis of randomized controlled trials.International journal of colorectal disease · 2025Pooled it
- Negative pressure wound therapy versus conventional wound care in cancer surgical wounds: A meta-analysis of observational studies and randomised controlled trials.International wound journal · 2022Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2022Pooled it
- Effectiveness of 3-Day Prophylactic Negative Pressure Wound Therapy on Closed Abdominal Incisions in the Prevention of Wound Complications: A Randomized Controlled Trial.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Trial
- Negative-pressure wound therapy after stoma reversal in colorectal surgery: a randomized controlled trial.BJS open · 2021Trial
- [Single-use negative pressure therapy for prevention of wound healing disorders for primarily closed incisions : International consensus and practical recommendations for Germany].Chirurgie (Heidelberg, Germany) · 2026Review
- Negative pressure wound therapy for preventing wound complications following stoma reversal: A systematic review and meta-analysis of randomized controlled trials.Asia-Pacific journal of oncology nursing · 2025Review
- An update on "The use of negative pressure wound therapy following stoma reversal: a systematic review and meta-analysis of randomized controlled trials" by Drumm et al.International journal of colorectal disease · 2025Article
- Effectiveness of negative pressure wound therapy (NPWT) in preventing incisional surgical site infection after stoma closure: a single institutional retrospective study.Surgery today · 2025Article
- Review
- Comparison of Negative Pressure Wound Therapy Systems and Conventional Non-Pressure Dressings on Surgical Site Infection Rate After Stoma Reversal: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2025Review
- Effectiveness of Subcutaneous Negative-Suction Drain on Surgical Site Infection After Ileostomy Reversal: A Propensity Score Matching Analysis.Journal of clinical medicine · 2025Article
- Mechanically powered negative pressure dressing reduces surgical site infection after stoma reversal.Surgery open science · 2025Article
- Development of a novel nomogram for the prediction of surgical site infection risk after loop ileostomy closure.International journal of colorectal disease · 2024Article
- Observational
- Timing of Loop Ileostomy Closure Does Not Play a Pivotal Role in Terms of Complications-Results of the Liquidation of iLEOstomy (LILEO) Study.Journal of personalized medicine · 2024Article
- Micro-power negative pressure wound technique reduces risk of incision infection following loop ileostomy closure.World journal of gastrointestinal surgery · 2024Article
- A case series of prophylactic negative pressure wound therapy use with purse-string closure in stoma closure wounds in infants.Surgical case reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe aim of this study was to assess the usefulness of protective negative-pressure wound therapy (NPWT) in the reduction of wound healing complications (WHC) and surgical site infections (SSI) after diverting ileostomy closure in patients who underwent surgery for colorectal cancer.
methodsIn this prospective randomized clinical trial in a tertiary academic surgical center, patients who had colorectal cancer surgery with protective loop ileostomy and were scheduled to undergo ileostomy closure with primary wound closure from January 2016 to December 2018 were randomized to be treated with or without NPWT. The primary endpoint was the incidence of WHC. Secondary endpoints were incidence of SSI, length of postoperative hospital stay (LOS), and length of complete wound healing (CWH) time.
resultsWe enrolled 35 patients NPWT (24 males [68.6%]; mean age 61.6 ± 11.3 years), with NPWT and 36 patients (20 males [55.6%]; mean age 62.4 ± 11.3 years) with only primary wound closure (control group). WHC was observed in 11 patients (30.6%) in the control group and 3 (8.57%) in the NPWT group (p = 0.020). Patients in the NPWT group had a significantly lower incidence of SSI (2 [5.71%] vs. 8 [22.2%] in the control group; p = 0.046) as well as significantly shorter median CWH (7 [7-7] days vs. 7 [7-15.5] days, p = 0.030). There was no difference in median LOS between groups (3 [2.5-5] days in the control group vs. 4 [2-4] days in the NPWT group; p = 0.072).
conclusionsProphylactic postoperative NPWT after diverting ileostomy closure in colorectal cancer patients reduces the incidence of WRC and SSI. CLINICAL
trial registrationclinicaltrials.gov (NCT04088162).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.