Evidence map›Paper›PMID 33161481›Full record

ArticleCerebellum (London, England)2021

Tremor-Dominant Cervical Dystonia: a Cerebellar Syndrome.

Abhimanyu Mahajan, Lyndsey Schroder, Aleksander Rekhtman, Alok K Dwivedi, Lily L Wang, Alberto J Espay

Abstract read
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Understanding Anxiety in Cervical Dystonia: An Imaging Study.Movement disorders clinical practice · 2024
    Article
  4. Article
  5. Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Abhimanyu MahajanSection of Movement Disorders, Rush University Medical Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8807-6672
Lyndsey SchroderDepartment of Neurology, James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, 260 Stetson Street, Suite 2300, Cincinnati, OH, 45219, USA.
Aleksander RekhtmanDepartment of Radiology, University of Cincinnati, Cincinnati, OH, USA.
Alok K DwivediDepartment of Molecular and Translational Medicine, Division of Biostatistics and Epidemiology, Texas Tech University Health Sciences Center, El Paso, TX, USA.
Lily L WangDepartment of Radiology, University of Cincinnati, Cincinnati, OH, USA.
Alberto J EspayDepartment of Neurology, James J. and Joan A. Gardner Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, 260 Stetson Street, Suite 2300, Cincinnati, OH, 45219, USA. alberto.espay@uc.edu.
University of Cincinnati · USRush University Medical Center · USTexas Tech University · US

Funding

Dystonia Medical Research Foundation DMRF Clinical Fellowship Award
6 · The paper itself

Abstract

The objective of this study is to examine the role of the cerebellum in the tremor-dominant subtype of cervical dystonia (CD). CD patients with head tremor at onset (Tr-CD) were age- and sex-matched to CD patients without head tremor at onset (nTr-CD). All patients were evaluated for cerebellar disability using the Scale for the Assessment and Rating of Ataxia (SARA), gait variability using ProtoKinetics Zeno Walkway, and cerebellar volume analysis extracted from brain magnetic resonance imaging (MRI) using a semiquantitative scale. Compared to nTr-CD (n = 10, median age, 70.5 years), Tr-CD patients (n = 10, 71.5 years) exhibited higher median SARA scores (9 vs 7.5, p = 0.03) and greater median gait variability index (131 vs 124, p = 0.03). SARA scores inversely correlated with cerebellar volume in all patients (- 0.4, p = 0.04). Tr-CD patients exhibited greater superior vermian atrophy than nTr-CD patients (p = 0.01). Head tremor at onset heralds a CD subtype with prominent axial cerebellar disability and atrophy of the superior vermis of the cerebellum.

Indexed as

AdultAgedCerebellumFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSyndromeTorticollisTremorCerebellumDystoniaGaitImagingTremor

Identifiers

PMID33161481
OpenAlexW3095219109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.