Evidence map›Paper›PMID 33161412›Full record

ArticleThe pharmacogenomics journal2021

Implications of venous thromboembolism GWAS reported genetic makeup in the clinical outcome of ovarian cancer patients.

Valéria Tavares, Ricardo Pinto, Joana Assis, Sara Coelho, Mariana Brandão, Sara Alves, Deolinda Pereira, Rui Medeiros

Abstract read
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In one paragraph

Article in The pharmacogenomics journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Valéria TavaresMolecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology of Porto, Edificio Laboratórios, 1° piso, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.
Ricardo PintoMolecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology of Porto, Edificio Laboratórios, 1° piso, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.
Joana AssisMolecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology of Porto, Edificio Laboratórios, 1° piso, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.
Sara CoelhoOncology Department, Portuguese Institute of Oncology, 4200-072, Porto, Portugal.
Mariana BrandãoOncology Department, Portuguese Institute of Oncology, 4200-072, Porto, Portugal.
Sara AlvesOncology Department, Portuguese Institute of Oncology, 4200-072, Porto, Portugal.
Deolinda PereiraMolecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology of Porto, Edificio Laboratórios, 1° piso, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal.
Rui MedeirosMolecular Oncology and Viral Pathology Group, Portuguese Institute of Oncology of Porto, Edificio Laboratórios, 1° piso, Rua Dr. António Bernardino de Almeida, 4200-072, Porto, Portugal. ruimedei@ipoporto.min-saude.pt.ORCID http://orcid.org/0000-0003-3010-8373
Instituto Português de Oncologia Francisco Gentil · PTFernando Pessoa University · PTInstitut Jules Bordet · BEUniversidade do Porto · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) represents the most lethal gynaecological neoplasia. Conversely, venous thromboembolism (VTE) and OC are intricately connected, with many haemostatic components favouring OC progression. In light of this bilateral relationship, genome-wide association studies (GWAS) have reported several single-nucleotide polymorphisms (SNPs) associated with VTE risk that could be used as predictors of OC clinical outcome for better therapeutic management strategies. Thus, the present study aimed to analyse the impact of VTE GWAS-identified SNPs on the clinical outcome of 336 epithelial ovarian cancer (EOC) patients. Polymorphism genotyping was performed using the TaqMan

Indexed as

AllelesCarcinoma, Ovarian EpithelialContactinsDisease-Free SurvivalFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMembrane Transport ProteinsOvarian NeoplasmsPolymorphism, Single NucleotideVenous ThromboembolismContactinsMembrane Transport Proteins

Identifiers

PMID33161412
OpenAlexW3103463914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.