Evidence map›Paper›PMID 33161376›Full record

ArticleRMD open2020

Efficacy and safety of tocilizumab in giant cell arteritis: a single centre NHS experience using imaging (ultrasound and PET-CT) as a diagnostic and monitoring tool.

Alwin Sebastian, Abdul Kayani, Diana Prieto-Pena, Alessandro Tomelleri, Madeline Whitlock, Jonathan Mo, Niels van der Geest, Bhaskar Dasgupta

Abstract read
In one paragraph

Article in RMD open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Diagnosing vasculitis with ultrasound: findings and pitfalls.Therapeutic advances in musculoskeletal disease · 2024
    Review
  10. Article
  11. [Imaging of large vessel vasculitis].Zeitschrift fur Rheumatologie · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Large-vessel vasculitis.Nature reviews. Disease primers · 2022
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alwin SebastianRheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea,UK.ORCID 0000-0002-9562-6748
Abdul KayaniRheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea,UK.
Diana Prieto-PenaRheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea,UK.
Alessandro TomelleriRheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea,UK.ORCID 0000-0002-5440-2078
Madeline WhitlockRheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea,UK.
Jonathan MoRadiology, Southend Hospital NHS Trust, Westcliff-on-sea,UK.
Niels van der GeestRheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Bhaskar DasguptaRheumatology, Southend University Hospital NHS Foundation Trust, Westcliff-on-Sea,UK bhaskar.dasgupta@southend.nhs.uk.ORCID 0000-0002-5523-6534

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tocilizumab (TCZ), an IL-6 receptor blocker, is approved for relapsing, refractory giant cell arteritis (GCA). We report real-life clinical experience with TCZ in GCA including assessment of responses on imaging (ultrasound (US) and 18F-Fluorodeoxyglucose Positron Emission Tomography-computed Tomography (

Indexed as

Antibodies, Monoclonal, HumanizedGiant Cell ArteritisAgedFemaleHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyQuality of LifeState MedicineAntibodies, Monoclonal, HumanizedtocilizumabGiant Cell ArteritisGlucocorticoidsSystemic vasculitisUltrasonography

Identifiers

PMID33161376
PMCPMC7856116

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.