Evidence map›Paper›PMID 33161094›Full record

ArticleCellular signalling2021

Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity.

Maíra de Assis Lima, Suély Vieira da Silva, Orlando Serrano-Garrido, Maren Hülsemann, Luana Santos-Neres, Juan Carlos Rodríguez-Manzaneque, Louis Hodgson, Vanessa M Freitas

Open access · greenAbstract read
In one paragraph

Article in Cellular signalling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Decoding Rho GTPase signalling networks in directed cell migration.Frontiers in cell and developmental biology · 2026
    Review
  4. Article
  5. Article
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  8. Extracellular Matrix Regulation in Physiology and in Brain Disease.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Maíra de Assis LimaDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 1524, Ed Biomédicas 1 sala 428, São Paulo, SP 05508-000, Brazil. Electronic address: mlima@usp.br.
Suély Vieira da SilvaDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 1524, Ed Biomédicas 1 sala 428, São Paulo, SP 05508-000, Brazil. Electronic address: suelyvieira@usp.br.
Orlando Serrano-GarridoGENYO, Centre for Genomics and Oncological Research, Avenida de la Ilustración, 114, Granada 18016, Spain. Electronic address: orlando.serrano@genyo.es.
Maren HülsemannDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, 10461, United States of America, Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York, 10461, United States of America. Electronic address: marenhuelsemann@gmail.com.
Luana Santos-NeresDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 1524, Ed Biomédicas 1 sala 428, São Paulo, SP 05508-000, Brazil. Electronic address: dos.santos.neres_luana@usp.br.
Juan Carlos Rodríguez-ManzanequeGENYO, Centre for Genomics and Oncological Research, Avenida de la Ilustración, 114, Granada 18016, Spain. Electronic address: juancarlos.rodriguez@genyo.es.
Louis HodgsonDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, 10461, United States of America, Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, New York, 10461, United States of America. Electronic address: louis.hodgson@einsteinmed.org.
Vanessa M FreitasDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes 1524, Ed Biomédicas 1 sala 428, São Paulo, SP 05508-000, Brazil. Electronic address: vfreitas@usp.br.
Universidade de São Paulo · BRAlbert Einstein College of Medicine · USPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ES

Funding

Multiplex Imaging of Signaling Pathways in Cell MotilityR35GM136226 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Louis Hodgson · 2020 to 2026
$5.3M
NIGMS NIH HHS R35 GM136226
6 · The paper itself

Abstract

ADAMTSs (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) are secreted proteases dependent on Zn

Indexed as

ADAMTS1 Proteincdc42 GTP-Binding ProteinCell LineCell MovementCell ProliferationCell SurvivalCRISPR-Cas SystemsFemaleFocal Adhesion Kinase 1Hepatocyte Growth FactorHumansPhosphorylationRNA, Guide, CRISPR-Cas SystemsSignal Transductionsrc-Family KinasesADAMTS1 ProteinADAMTS1 protein, humancdc42 GTP-Binding ProteinCDC42 protein, humanFocal Adhesion Kinase 1Hepatocyte Growth FactorRNA, Guide, CRISPR-Cas Systemssrc-Family Kinases

Identifiers

PMID33161094
PMCPMC7723338
OpenAlexW3094856711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.