Trial reportArchives of physical medicine and rehabilitation2021
Effects of Lower Thoracic Spinal Cord Stimulation on Bowel Management in Individuals With Spinal Cord Injury.
Trial report in Archives of physical medicine and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01659541 (Spinal Cord Stimulation With Wire Leads to Restore Cough), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Spinal Cord Stimulation With Wire Leads to Restore Cough
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.Frontiers in human neuroscience · 2026Pooled it
- Spinal cord stimulation: An emerging strategy for chronic pain relief after spinal cord injury.Neural regeneration research · 2026Article
- Spinal cord neuromodulation for autonomic recovery following spinal cord injury: a scoping review.Journal of neuroengineering and rehabilitation · 2026Article
- Article
- Mapping the Iceberg of Autonomic Recovery: Mechanistic Underpinnings of Neuromodulation following Spinal Cord Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Unintentionally intentional: unintended effects of spinal stimulation as a platform for multi-modal neurorehabilitation after spinal cord injury.Bioelectronic medicine · 2024Review
- Epidural Spinal Cord Stimulation for Spinal Cord Injury in Humans: A Systematic Review.Journal of clinical medicine · 2024Review
- Restoration of Over-Ground Walking via Non-Invasive Neuromodulation Therapy: A Single-Case Study.Journal of clinical medicine · 2023Article
- Impact of the cough stimulation system on the care burden and life quality of caregivers of tetraplegics.The journal of spinal cord medicine · 2023Article
- Spinal Cord Stimulation Prevents Autonomic Dysreflexia in Individuals with Spinal Cord Injury: A Case Series.Journal of clinical medicine · 2023Article
- Respiratory Complications and Weaning Considerations for Patients with Spinal Cord Injuries: A Narrative Review.Journal of personalized medicine · 2022Review
- Effects of restoration of cough via spinal cord stimulation on subject quality of life.Journal of clinical orthopaedics and trauma · 2022Article
- A Review of Functional Restoration From Spinal Cord Stimulation in Patients With Spinal Cord Injury.Neurospine · 2022Article
- Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review.Journal of clinical medicine · 2022Review
- Rapid development and rupture of a pneumatocele caused by pulmonary dissection in the early postoperative period of lung resection: a case report.AME case reports · 2022Article
- Article
- Effectiveness of Abdominal Functional Electrical Stimulation for Improving Bowel Function in People With a Spinal Cord Injury: A Study Protocol for a Double-Blinded Randomized Placebo-Controlled Clinical Trial.Topics in spinal cord injury rehabilitation · 2022Article
- Restoration of cough via spinal cord stimulation improves pulmonary function in tetraplegics.The journal of spinal cord medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo systematically determine whether use of the spinal cord stimulation (SCS) system to restore cough may improve bowel management (BM) in individuals with spinal cord injury (SCI).
designExperimental studies (clinical trial).
settingInpatient hospital setting for electrode insertion; outpatient setting for measurement of respiratory pressures; home setting for application of SCS.
participantsParticipants (N=5) with cervical SCI.
interventionA fully implantable SCS cough system was surgically placed in each subject. SCS was applied at home, 2-3 times/d, on a chronic basis, every time bowel regimen was performed and as needed for secretion management. Stimulus parameters were set at values resulting in near maximum airway pressure generation, which was used as an index of expiratory muscle strength. Participants also used SCS during their bowel routine.
main outcome measuresAirway pressure generation achieved with SCS. Weekly completion of Bowel Routine Log including BM time, mechanical measures, and medications used.
resultsMean pressure during spontaneous efforts was 30±8 cmH
conclusionsOur results of this pilot study suggest that SCS to restore cough may be a useful method to improve BM and life quality for both patients with SCI and their caregivers. Our results indicate that the improvement in BM is secondary to restoration of intra-abdominal pressure development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.