ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Reward Functioning Abnormalities in Adolescents at High Familial Risk for Depressive Disorders.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Targeting positive valence systems function in children of mothers with depressive symptoms: A pilot randomized trial of an RDoC-Informed preventive intervention.Behaviour research and therapy · 2023Trial
- Neural response to reward uncertainty in adolescents with mood and anxiety symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nature. Mental health · 2026Article
- Reward-specific learning parameters change across normative adolescent development and are blunted in youth with high risk for depression.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Transdiagnostic divergent neural development of reward anticipation in early adolescents at risk for depression and psychosis.Developmental cognitive neuroscience · 2026Article
- Multimodal prediction of future depressive symptoms in adolescents.BMC psychiatry · 2025Article
- Multimodal Prediction of Future Depressive Symptoms in Adolescents.Research square · 2025Article
- Development of Self-Reported Reward Responsiveness and Inhibitory Control and the Role of Clinical and Neural Predictors.Journal of personality · 2025Article
- Reward-Related Brain Activity Mediates the Relationship Between Decision-Making Deficits and Pediatric Depression Symptom Severity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Computational Modeling Differentiates Learning Rate From Reward Sensitivity Deficits Produced by Early-Life Adversity in a Rodent Touchscreen Probabilistic Reward Task.Biological psychiatry global open science · 2024Article
- Stress exposure in at-risk, depressed, and suicidal adolescents.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Effects of GABA, Sex, and Stress on Reward Learning in Current and Remitted Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Multi-modal assessment of reward functioning in adolescent anhedonia.Psychological medicine · 2023Article
- Default Mode and Frontoparietal Network Dynamics: Associations with Familial Risk for Depression and Stress Sensitivity.Journal of mood and anxiety disorders · 2023Article
- Reward-related predictors of symptom change in behavioral activation therapy for anhedonic adolescents: a multimodal approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Neural sensitivity to peer feedback and depression symptoms in adolescents: a 2-year multiwave longitudinal study.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Reduced cortical surface area globally and in reward-related cortex is associated with elevated depressive symptoms in preschoolers.Journal of affective disorders · 2022Article
- Neural and peripheral markers of reward during positive social evaluation are associated with less clinician-rated depression symptom severity in adolescence.Comprehensive psychoneuroendocrinology · 2022Article
- The role of educational attainment and brain morphology in major depressive disorder: Findings from the ENIGMA major depressive disorder consortium.Journal of psychopathology and clinical science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundA parental history of major depressive disorder (MDD) is an established risk factor for MDD in youth, and clarifying the mechanisms related to familial risk transmission is critical. Aberrant reward processing is a promising biomarker of MDD risk; accordingly, the aim of this study was to test behavioral measures of reward responsiveness and underlying frontostriatal resting activity in healthy adolescents both with (high-risk) and without (low-risk) a maternal history of MDD.
methodsLow-risk and high-risk 12- to 14-year-old adolescents completed a probabilistic reward task (n = 74 low-risk, n = 27 high-risk) and a resting-state functional magnetic resonance imaging scan (n = 61 low-risk, n = 25 high-risk). Group differences in response bias toward reward and resting ventral striatal and medial prefrontal cortex (mPFC) fractional amplitude of low-frequency fluctuations (fALFFs) were examined. Computational modeling was applied to dissociate reward sensitivity from learning rate.
resultsHigh-risk adolescents showed a blunted response bias compared with low-risk adolescents. Computational modeling analyses revealed that relative to low-risk adolescents, high-risk adolescents exhibited reduced reward sensitivity but similar learning rate. Although there were no group differences in ventral striatal and mPFC fALFFs, groups differed in their relationships between mPFC fALFFs and response bias. Specifically, among high-risk adolescents, higher mPFC fALFFs correlated with a blunted response bias, whereas there was no fALFFs-response bias relationship among low-risk youths.
conclusionsHigh-risk adolescents exhibit reward functioning impairments, which are associated with mPFC fALFFs. The blunted response bias-mPFC fALFFs association may reflect an excessive mPFC-mediated suppression of reward-driven behavior, which may potentiate MDD risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.