Evidence map›Paper›PMID 33160848›Full record

ArticleUrologic oncology2021

Prostate cancer recurrence in patients with negative or equivocal conventional imaging: A role for

Eric H Kim, Barry A Siegel, Eugene J Teoh, Gerald L Andriole, LOCATE Study Group

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in Urologic oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02680041 (The Impact of 18F Fluciclovine), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02680041 phase3completednot on this map

The Impact of 18F Fluciclovine (FACBC) PET/CT (Positron Emission Computed Tomography) on Management of Patients With Rising PSA (Prostate-specific Antigen) After Initial Prostate Cancer Treatment

TypeinterventionalSponsorBlue Earth DiagnosticsRan2016 to 2017Enrolled221ConditionsProstate CancerArms18F-fluciclovine PET CT
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Clinical practice in prostate PET imaging.Therapeutic advances in medical oncology · 2023
    Review
  3. Oligometastatic Prostate Cancer: Current Status and Future Challenges.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  4. [Cancers · 2022
    Article
  5. Positivity Rate of [Molecular imaging and biology · 2022
    Article
  6. Review
  7. Clinical utility ofAmerican journal of nuclear medicine and molecular imaging · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Eric H KimDivision of Urologic Surgery, Department of Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO,. Electronic address: ehkim@wustl.edu.
Barry A SiegelDivision of Nuclear Medicine, Mallinckrodt Institute of Radiology and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO.
Eugene J TeohBlue Earth Diagnostics Ltd, the Oxford Science Park, Robert Robinson Avenue, Oxford OX4 4GA, UK.
Gerald L AndrioleDivision of Urologic Surgery, Department of Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO.
LOCATE Study Group
Washington University in St. Louis · USBlue Earth Diagnostics (United Kingdom) · GBMallinckrodt (United States) · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

introductionDespite improvements in overall survival, biochemical recurrence of prostate cancer, characterized by rising prostate-specific antigen (PSA) levels after curative intent primary therapy, remains common. With the advent of highly sensitive molecular imaging, men with limited metastatic disease burden, or oligometastatic prostate cancer, are increasingly being identified. The LOCATE trial (NCT02680041) assessed the impact of positron emission tomography (PET) with

methodsEligible men (≥18 years; prior curative intent treatment of prostate cancer; recurrence based on rising PSA; negative/equivocal conventional imaging) underwent

resultsOf 213 enrolled patients, 164 (77%) had undergone prostatectomy as their initial treatment; their median PSA was 0.57ng/ml. For the 49 patients with an intact prostate, the median PSA was 5.5ng/ml. The overall

conclusionEven at low PSA levels,

Indexed as

Carboxylic AcidsCyclobutanesPositron Emission Tomography Computed TomographyHumansMaleNeoplasm MetastasisNeoplasm Recurrence, LocalProspective StudiesProstatic NeoplasmsCarboxylic AcidsCyclobutanesfluciclovine F-18(18)F-fluciclovineBiochemical recurrenceOligometastasesPositron emission tomographyProstatic neoplasms

Identifiers

PMID33160848
PMCPMC8491981
OpenAlexW3096388854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.