ArticleBMC research notes2020
A snapshot of Plasmodium falciparum malaria drug resistance markers in Sudan: a pilot study.
Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Spatio-temporal trends of artemisinin-based combination therapy efficacy from 2010 to 2024 in sub-Saharan Africa: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Epidemiological trends of malaria in Sennar State, Sudan.Malaria journal · 2025Article
- Undetected circulation of major arboviruses in West Sudan: urging for institutionalizing multisectoral one health strategy for the preparedness, prevention, and control of zoonotic arboviral diseases.BMC research notes · 2024Article
- The challenge of triple intestinal parasite infections in immigrants-A call for comprehensive differential diagnosis.Clinical case reports · 2024Article
- Potential impact of climatic factors on malaria in Rwanda between 2012 and 2021: a time-series analysis.Malaria journal · 2024Article
- Severe coinfection of dengue and malaria: A case report.Clinical case reports · 2024Article
- Blood meal profile and positivity rate with malaria parasites among different malaria vectors in Sudan.Malaria journal · 2022Article
- Article
- Prevalence of antifolate drug resistance markers in Plasmodium vivax in China.Frontiers of medicine · 2022Article
- Assessment of genetic diversity of Plasmodium falciparum circumsporozoite protein in Sudan: the RTS,S leading malaria vaccine candidate.Malaria journal · 2021Article
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Authors and funding
17 authors at 9 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesMalaria infection is still known to be a worldwide public health problem, especially in tropical and sub-tropical African countries like Sudan. A pilot study conducted to describe the trend of P. falciparum drug resistance markers in 2017-2018 in comparison to CQ and AS/SP eras in Sudan. The Pfcrt, Pfmdr-1, Pfdhfr, and Pfdhps genes were investigated. Data deposited by the worldwide antimalarial resistance network was consulted, and the molecular markers previously reported from Sudan were analyzed.
resultsDrug molecular markers analysis was successfully done on 20 P. falciparum isolates. The Pfcrt K76 showed high frequency; 16 (80%). For the Pfmdr-1, 9 (45%) isolates were carrying the N86 allele, and 11 (55%) were 86Y allele. While the Y184F of the Pfmdr-1 showed a higher frequency of 184F compared to Y184; 16 (80%) and 4 (20%), respectively. In the Pfdhfr, 51I allele showed higher frequency compared to N51; 18 (90%) and 2 (10%), respectively. For S108N, 18 (90%) were 108 N and 2 (10%) were S108. In the Pfdhps, all isolates were carrying the mutant alleles; 437G and 540E. The frequency distribution of the Pfcrt, Pfmdr-1, Pfdhfr, Pfdhps was significantly different across the whole years in Sudan.
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