SynthesisCritical care (London, England)2020
Performance of the cuff leak test in adults in predicting post-extubation airway complications: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Diagnostic efficacy of sonographic measurement of laryngeal air column width difference for predicting the risk of post-extubation stridor: A meta-analysis of observational studies.Frontiers in medicine · 2023Pooled it
- Effect of the extubation predictive score (ExPreS) on reintubation in the ICU: a randomized controlled trial.Critical care (London, England) · 2026Trial
- Effect of Reintubation Within 48 Hours on Mortality in Critically Ill Patients After Planned Extubation.Respiratory care · 2024Trial
- Prediction of post-extubation stridor using ultrasound measurement of subglottic airway diameter.The ultrasound journal · 2026Article
- Halogen checker may be useful to cuff leak test.Journal of anesthesia · 2026Article
- Diagnostic accuracy of tests for assessing readiness for liberation from mechanical ventilation in adults: an overview of reviews.Journal of intensive care · 2026Review
- Bridging the Gap: The Role of Non-Invasive Respiratory Supports in Weaning from Invasive Mechanical Ventilation.Journal of clinical medicine · 2025Review
- Oropharyngeal ultrafast ultrasound measurements in mechanically ventilated critically ill patients do not identify post-extubation stridor.Critical care (London, England) · 2025Observational
- Review
- Airway Ultrasound: A Narrative Review of Present Use and Future Applications in Anesthesia.Healthcare (Basel, Switzerland) · 2025Review
- Challenge of tracheal extubation and tube exchange of a difficult airway: a narrative review.Journal of anesthesia · 2025Review
- Increased cuff-leak pressure after abdominal and spine surgeries: a simple and novel cuff-leak test for tracheal extubation.Journal of anesthesia · 2025Article
- Article
- Extubation outcomes in critically ill post-craniotomy patients: A retrospective cohort study.PloS one · 2025Article
- Outcomes Associated With Airway Management of Adult Trauma Patients Admitted to Surgical Intensive Care.Cureus · 2024Article
- Position Statement of ISCCM Committee on Weaning from Mechanical Ventilator.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Three Cases of Persistent Laryngeal Edema Postradiation Therapy.Anesthesia progress · 2024Article
- Article
- Extubation After Acute Brain Injury: An Unsolved Dilemma!!Neurocritical care · 2024Article
- Impact of delay extubation on the reintubation rate in patients after cervical spine surgery: a retrospective cohort study.Journal of orthopaedic surgery and research · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical practice guidelines recommend performing a cuff leak test in mechanically ventilated adults who meet extubation criteria to screen those at high risk for post-extubation stridor. Previous systematic reviews demonstrated excellent specificity of the cuff leak test but disagreed with respect to sensitivity. We conducted a systematic review and meta-analysis to assess the diagnostic accuracy of the cuff leak test for predicting post-extubation airway complications in intubated adult patients in critical care settings.
methodsWe searched Medline, EMBASE, Scopus, ISI Web of Science, the Cochrane Library for eligible studies from inception to March 16, 2020, without language restrictions. We included studies that examined the diagnostic accuracy of cuff leak test if post-extubation airway obstruction after extubation or reintubation was explicitly reported as the reference standard. Two authors in duplicate and independently assessed the risk of bias using the Quality Assessment for Diagnostic Accuracy Studies-2 tool. We pooled sensitivities and specificities using generalized linear mixed model approach to bivariate random-effects meta-analysis. Our primary outcomes were post-extubation airway obstruction and reintubation.
resultsWe included 28 studies involving 4493 extubations. Three studies were at low risk for all QUADAS-2 risk of bias domains. The pooled sensitivity and specificity of cuff leak test for post-extubation airway obstruction were 0.62 (95% CI 0.49-0.73; I
conclusionsThe cuff leak test has excellent specificity but moderate sensitivity for post-extubation airway obstruction. The high specificity suggests that clinicians should consider intervening in patients with a positive test, but the low sensitivity suggests that patients still need to be closely monitored post-extubation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.