ArticleRadiation oncology (London, England)2020
The decreased mean platelet volume is associated with poor prognosis in patients with oropharyngeal cancer treated with radiotherapy.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic significance of mean platelet volume in patients with lung cancer: a meta-analysis.The Journal of international medical research · 2022Pooled it
- A cytokine-based serum proteomic score is a prognostic biomarker for immunotherapy in head and neck cancer.Cancer immunology, immunotherapy : CII · 2025Article
- Mean platelet volume as a potential biomarker for survival outcomes in ovarian clear cell carcinoma.International journal of clinical oncology · 2023Article
- Mean platelet volume and the association with all-cause mortality and cardiovascular mortality among incident peritoneal dialysis patients.BMC cardiovascular disorders · 2023Article
- A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma.Cancer medicine · 2023Article
- Mean platelet volume may predict all-cause and cardiovascular mortality among incident peritoneal dialysis patients.Renal failure · 2023Article
- Preoperative mean platelet volume is a prognostic biomarker for survival in patients with gastric cancer: A cohort study.Medicine · 2022Article
- A predictive model for advanced oropharyngeal cancer patients treated with chemoradiation.BMC cancer · 2022Article
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9 authors.
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Abstract
backgroundThere is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different types of cancer. However, the prognostic role of the MPV in head and neck squamous cell cancer (HNSCC) is currently discussed controversially. The present study was performed to analyze and further elucidate the prognostic significance of the MPV in HNSCC.
methodsA total of 319 oropharyngeal squamous cell cancer (OPSCC) patients treated with radiotherapy at a tertiary academic center were enrolled in the present study. Kaplan-Meier method as well as uni- and multivariate Cox proportional hazards were used to evaluate the impact of MPV on cancer-specific survival (CSS), locoregional control (LC) and recurrence-free survival (RFS).
resultsThe median MPV was 10.30 fL (mean 10.26 ± 1.17fL). Univariate analyses showed a significant association of the MPV with CSS (HR 0.85, 95% CI 0.74-0.98, p = 0.025), LC (HR 0.86, 95% CI 0.74-0.99, p = 0.034) and RFS (HR 0.87, 95% CI 0.76-0.996; p = 0.043). In multivariate analysis, the MPV remained an independent prognostic factor for CSS (HR 0.77, 95% CI 0.63-0.93, p = 0.008), LC (HR 0.80, 95% CI 0.65-0.98, p = 0.030), and RFS (HR 0.83, 95% CI 0.685-0.999, p = 0.049).
conclusionsOur findings indicate that the MPV is a prognostic marker in OPSCC patients and may contribute to future individual risk assessment.
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