ArticleBMC health services research2020
At the intersection of precision medicine and population health: an implementation-effectiveness study of family health history based systematic risk assessment in primary care.
Article in BMC health services research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01956773 (Family Health History in Diverse Care Settings), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Family Health History in Diverse Care Settings
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- A Cluster Randomized Trial of a Family Health History Platform to Identify and Manage Patients at Increased Risk for Colorectal Cancer.Journal of general internal medicine · 2023Trial
- Breaking barriers to completing genetic testing for inherited breast cancer among at-risk Black women using a community-based participatory research approach.HGG advances · 2026Article
- Article
- Enhancing patient representation learning with inferred family pedigrees improves disease risk prediction.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Identification of Individuals With Hereditary Cancer Risk Through Multiple Data Sources: A Population-Based Method Using the GARDE Platform and The Utah Population Database.JCO clinical cancer informatics · 2024Article
- Experiences across a genetic screening and testing programme pathway: a qualitative study of mammogram patient perspectives.BMJ open · 2024Article
- The Canadian Landscape of Genetics and Genomics in Nursing: A Policy Document Analysis.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2023Article
- Implementation-effectiveness trial of systematic family health history based risk assessment and impact on clinical disease prevention and surveillance activities.BMC health services research · 2022Article
- Review
- Current state and future directions of genomic medicine in aortic dissection: A path to prevention and personalized care.Seminars in vascular surgery · 2022Review
- Application of P4 (Predictive, Preventive, Personalized, Participatory) Approach to Occupational Medicine.La Medicina del lavoro · 2022Review
- Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients.Journal of personalized medicine · 2021Article
- Clinical implementation of an oncology-specific family health history risk assessment tool.Hereditary cancer in clinical practice · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundRisk assessment is a precision medicine technique that can be used to enhance population health when applied to prevention. Several barriers limit the uptake of risk assessment in health care systems; and little is known about the potential impact that adoption of systematic risk assessment for screening and prevention in the primary care population might have. Here we present results of a first of its kind multi-institutional study of a precision medicine tool for systematic risk assessment.
methodsWe undertook an implementation-effectiveness trial of systematic risk assessment of primary care patients in 19 primary care clinics at four geographically and culturally diverse healthcare systems. All adult English or Spanish speaking patients were invited to enter personal and family health history data into MeTree, a patient-facing family health history driven risk assessment program, for 27 medical conditions. Risk assessment recommendations followed evidence-based guidelines for identifying and managing those at increased disease risk.
resultsOne thousand eight hundred eighty-nine participants completed MeTree, entering information on N = 25,967 individuals. Mean relatives entered = 13.7 (SD 7.9), range 7-74. N = 1443 (76.4%) participants received increased risk recommendations: 597 (31.6%) for monogenic hereditary conditions, 508 (26.9%) for familial-level risk, and 1056 (56.1%) for risk of a common chronic disease. There were 6617 recommendations given across the 1443 participants. In multivariate analysis, only the total number of relatives entered was significantly associated with receiving a recommendation.
conclusionsA significant percentage of the general primary care population meet criteria for more intensive risk management. In particular 46% for monogenic hereditary and familial level disease risk. Adopting strategies to facilitate systematic risk assessment in primary care could have a significant impact on populations within the U.S. and even beyond.
trial registrationClinicaltrials.gov number NCT01956773 , registered 10/8/2013.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.