Evidence map›Paper›PMID 33160321›Full record

ArticleBMC nephrology2020

Design and methodology of the Aging Nephropathy Study (AGNES): a prospective cohort study of elderly patients with chronic kidney disease.

Venceslau A Coelho, Giovani Gn Santos, Carla M Avesani, Cicero Italo L Bezerra, Luana Cristina A Silva, Julia C Lauar, Bengt Lindholm, Peter Stenvinkel, Wilson Jacob-Filho, Irene L Noronha and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04132492 (AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04132492 completednot on this map

AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients

TypeobservationalSponsorUniversity of Sao Paulo General HospitalRan2019 to 2024Enrolled151ConditionsChronic Kidney Diseases, Elderly, Mortality, Renal Replacement TherapyArmsno intervention
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Venceslau A CoelhoLIM 66, Division of Geriatrics, Faculdade de Medicina Universidade de Sao Paulo, Sao Paulo, Brazil.
Giovani Gn SantosDivision of Geriatrics, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Carla M AvesaniDivision of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Cicero Italo L BezerraDivision of Nephrology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Luana Cristina A SilvaDivision of Nephrology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Julia C LauarDivision of Nephrology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Bengt LindholmDivision of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Peter StenvinkelDivision of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Wilson Jacob-FilhoLIM 66, Division of Geriatrics, Faculdade de Medicina Universidade de Sao Paulo, Sao Paulo, Brazil.
Irene L NoronhaDivision of Nephrology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Roberto ZatzDivision of Nephrology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Rosa M A MoysésDivision of Nephrology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.
Rosilene M EliasDivision of Nephrology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil. rosilenemotta@hotmail.com.ORCID 0000-0003-2212-041X
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRKarolinska Institutet · SE

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/04045-5
6 · The paper itself

Abstract

backgroundRenal replacement therapy (RRT) is usually indicated for patients with chronic kidney disease (CKD) with glomerular filtration rate below 10 ml/ml/min/1.73m

methodsAGNES is a prospective observational cohort that aim to investigate clinical, biochemical and demographic factors associated with RRT initiation and mortality of patients with CKD stage 4 or 5 who are aged 70 years and older. We plan to include 200 patients over 5 years. Clinically stable outpatients on conservative management for at least 6 months will be recruited from the Nephrogeriatric Clinic at the Hospital das Clinicas da Universidade de Sao Paulo, Brazil. Eligible patients are submitted to a full clinical examination, geriatric assessment, and blood test at baseline. Following the baseline visit the patients are being monitored during an observational follow up period of at least 12 months during which patients will be contacted in the clinic at their regular follow up or by phone until either RRT initiation or death occurs. This cohort includes evaluation of cognition by the education-adjusted 10-point Cognitive Screener (10-CS), frailty by Fried index score, a complete nutritional assessment (by body composition assessment, global subjective assessment and dietary intake), comorbidities by Charlson comorbidity index and biochemical markers including FGF-23 and Klotho. DISCUSSION: The AGNES cohort, a real-world study of current clinical practice in elderly patients with advanced CKD prior to dialysis initiation, will shed light into progression of CKD and its complications, indications of RRT and factors determining survival. This investigation will elucidate to what extent geriatric conditions, nutritional status and clinical factors are associated with survival, quality of life and RRT initiation in elderly CKD patients not yet on dialysis.

trial registrationRegistered on ClinicalTrials.gov on 18 October 2019 ( NCT04132492 ).

Indexed as

AgedAge FactorsAgingCognition DisordersComorbidityDiabetes ComplicationsFibroblast Growth Factor-23FrailtyHeart FailureHumansProspective StudiesRenal Insufficiency, ChronicResearch DesignRisk FactorsSleep Wake DisordersFibroblast Growth Factor-23CognitionDialysisEnd stage renal diseaseFragilityMortalityRenal replacement therapySleep

Identifiers

PMID33160321
PMCPMC7648411
OpenAlexW3096470053

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.