Evidence map›Paper›PMID 33160248›Full record

ArticleJournal of the neurological sciences2020

It's tricky: Rating alleviating maneuvers in cervical dystonia.

Elizabeth Cisneros, Glenn T Stebbins, Qiyu Chen, Jeanne P Vu, Casey N Benadof, Zheng Zhang, Richard L Barbano, Susan H Fox, Christopher G Goetz, Joseph Jankovic and 11 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the neurological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Tardive cervical dystonia.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  4. Article
  5. Does Raising the Arms Modify Head Tremor Severity in Cervical Dystonia?Tremor and other hyperkinetic movements (New York, N.Y.) · 2021
    Article
  6. Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021
    Review
  7. Sports-Related Dystonia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 2 countries.

Elizabeth CisnerosInstitute for Neural Computation, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States of America. Electronic address: e1cisner@ucsd.edu.
Glenn T StebbinsDepartment of Neurological Sciences, Rush University Medical Center, 1620 W Harrison St, Chicago, IL 60612, United States of America. Electronic address: glenn_stebbins@rush.edu.
Qiyu ChenInstitute for Neural Computation, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States of America. Electronic address: qic050@ucsd.edu.
Jeanne P VuInstitute for Neural Computation, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States of America.
Casey N BenadofInstitute for Neural Computation, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States of America.
Zheng ZhangInstitute for Neural Computation, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States of America.
Richard L BarbanoDepartment of Neurology, University of Rochester, 500 Joseph C. Wilson Blvd, Rochester, NY 14627, United States of America. Electronic address: richard_barbano@urmc.rochester.edu.
Susan H FoxMovement Disorder Clinic, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; Medical Sciences Building, 1 King's College Cir, Toronto, ON M5S 1A8, Canada. Electronic address: susan.fox@uhnresearch.ca.
Christopher G GoetzDepartment of Neurological Sciences, Rush University Medical Center, 1620 W Harrison St, Chicago, IL 60612, United States of America. Electronic address: christopher_goetz@rush.edu.
Joseph JankovicDepartment of Neurology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States of America. Electronic address: josephj@bcm.edu.
Hyder A JinnahDepartments of Neurology and Human Genetics, Emory University, 1365 Clifton Rd building b suite 2200, Atlanta, GA 30322, United States of America. Electronic address: hjinnah@emory.edu.
Joel S PerlmutterDepartment of Neurology, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, United States of America; Departments of Radiology, Neuroscience, Physical Therapy, and Occupational Therapy, Washington University School of Medicine, 660 S Euclid Ave, St. Louis, MO 63110, United States of America. Electronic address: perlmutterjoel@wustl.edu.
Charles H AdlerDepartment of Neurology, Mayo Clinic College of Medicine, 200 1st St SW, Rochester, MN 55905, United States of America. Electronic address: cadler@mayo.edu.
Stewart A FactorDepartment of Neurology, Emory University School of Medicine, 201 Dowman Dr, Atlanta, GA 30322, United States of America. Electronic address: sfactor@emory.edu.
Stephen G ReichDepartment of Neurology, University of Maryland Medical Centre, 22 S Greene St, Baltimore, MD 21201, United States of America. Electronic address: sreich@som.umaryland.edu.
Ramon RodriguezUF Department of Neurology, 1149 Newell Dr, Gainesville, FL 32611, United States of America. Electronic address: ramrod@ufl.edu.
Lawrence L SevertDepartment of Neurology, Beth Israel Medical Center, 529 W 42nd St # 6K, New York, NY 10036, United States of America.
Natividad P StoverDepartment of Neurology, The University of Alabama, Tuscaloosa, AL 35487, United States of America. Electronic address: npstover@uab.edu.
Brian D BermanDepartment of Neurology, Virginia Commonwealth University, 1101 East Marshall Street, PO Box 980599, Richmond, VA 23298-0599, United States of America. Electronic address: Brian.Berman@vcuhealth.org.
Cynthia L ComellaDepartment of Neurological Sciences, Rush University Medical Center, 1620 W Harrison St, Chicago, IL 60612, United States of America. Electronic address: cynthia_comella@rush.edu.
David A PetersonInstitute for Neural Computation, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, United States of America; CNL-S, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, United States of America. Electronic address: dap@salk.edu.
University of California, San Diego · USRush University Medical Center · USEmory University · USBaylor College of Medicine · USMayo Clinic · USMount Sinai Beth Israel · USToronto Western Hospital · CAUniversity of Alabama · USUniversity of Florida · USUniversity of Maryland Medical Center · USUniversity of Rochester · USVirginia Commonwealth University · USWashington University in St. Louis · US

Funding

Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
Dystonia CoalitionU54TR001456 · NCATS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2015 to 2016
$2.5M
NCATS NIH HHS U54 TR001456NINDS NIH HHS U54 NS065701NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

objectivesTo investigate hypothesized sources of error when quantifying the effect of the sensory trick in cervical dystonia (CD) with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS-2), test strategies to mitigate them, and provide guidance for future research on the sensory trick.

methodsPrevious analyses suggested the sensory trick (or "alleviating maneuver", AM) item be removed from the TWSTRS-2 because of its poor clinimetric properties. We hypothesized three sources of clinimetric weakness for rating the AM: 1) whether patients were given sufficient time to demonstrate their AM; 2) whether patients' CD was sufficiently severe for detecting AM efficacy; and 3) whether raters were inadvertently rating the item in reverse of scale instructions. We tested these hypotheses with video recordings and TWSTRS-2 ratings by one "site rater" and a panel of five "video raters" for each of 185 Dystonia Coalition patients with isolated CD.

resultsOf 185 patients, 23 (12%) were not permitted sufficient testing time to exhibit an AM, 23 (12%) had baseline CD too mild to allow confident rating of AM effect, and 1 site- and 1 video-rater each rated the AM item with a reverse scoring convention. When these confounds were eliminated in step-wise fashion, the item's clinimetric properties improved.

conclusionsThe AM's efficacy can contribute to measuring CD motor severity by addressing identified sources of error during its assessment and rating. Given the AM's sensitive diagnostic and potential pathophysiologic significance, we also provide guidance on modifications to how AMs can be assessed in future CD research.

Indexed as

Dystonic DisordersTorticollisHumansVideo RecordingCervical dystoniaClinimetricsSensorimotor integrationSensory trickSpasmodic torticollis

Identifiers

PMID33160248
PMCPMC7728456
OpenAlexW3095250918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.