Evidence map›Paper›PMID 33160069›Full record

ArticlePharmacological research2021

Arginine vasopressin receptor 2 activation promotes microvascular permeability in sepsis.

Ernesto Lopez, Satoshi Fukuda, Katalin Modis, Osamu Fujiwara, Baigal Enkhtaivan, Raul Trujillo-Abarca, Koji Ihara, Francisco Lima-Lopez, Dannelys Perez-Bello, Csaba Szabo and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Endothelial cell metabolism in sepsis.World journal of emergency medicine · 2023
    Review
  6. Article
  7. Article
  8. Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Ernesto LopezDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Satoshi FukudaDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Katalin ModisDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA; Department of Surgery, University of Texas Medical Branch Galveston, TX, USA.
Osamu FujiwaraDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Baigal EnkhtaivanDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Raul Trujillo-AbarcaDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Koji IharaDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA; Department of Plastic and Reconstructive Surgery, Kagoshima City Hospital, Kagoshima, Japan.
Francisco Lima-LopezDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA; Department of Surgery, University of Texas Medical Branch Galveston, TX, USA.
Dannelys Perez-BelloDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Csaba SzaboDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology, University of Fribourg, Fribourg, Switzerland.
Donald S ProughDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Perenlei EnkhbaatarDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: peenkhba@utmb.edu.
The University of Texas Medical Branch at Galveston · USKagoshima City Hospital · JPUniversity of Fribourg · CH

Funding

Etiology of Microvascular Changes in Gram-positive Sepsis: Mechanisms and Therapeutic OptionsR01GM097480 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ENKHBAATAR, PERENLEI · 2012 to 2022
$2.7M
NIGMS NIH HHS R01 GM097480
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) sepsis is a severe condition associated with vascular leakage and poor prognosis. The hemodynamic management of sepsis targets hypotension, but there is no specific treatment available for vascular leakage. Arginine vasopressin (AVP) has been used in sepsis to promote vasoconstriction by activating AVP receptor 1 (V

Indexed as

Methicillin-Resistant Staphylococcus aureusAngiopoietin-2AnimalsAntidiuretic AgentsAntidiuretic Hormone Receptor AntagonistsCapillary PermeabilityCells, CulturedDeamino Arginine VasopressinEndothelial CellsFemaleHemodynamicsHumansPhospholipase C betaPneumonia, StaphylococcalReceptors, VasopressinSepsisAngiopoietin-2Antidiuretic AgentsAntidiuretic Hormone Receptor AntagonistsAVPR2 protein, humanDeamino Arginine VasopressinPhospholipase C betaPLCB4 protein, humanReceptors, VasopressinTolvaptanEndotheliumMicrovascular hyperpermeabilitySepsisShockTolvaptan

Identifiers

PMID33160069
PMCPMC8075069
OpenAlexW3096863779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.