Evidence map›Paper›PMID 33160010›Full record

ArticleBehavioural brain research2021

Comparing neural correlates of conditioned inhibition between children with and without anxiety disorders - A preliminary study.

Anita Harrewijn, Elizabeth R Kitt, Rany Abend, Chika Matsumoto, Paola Odriozola, Anderson M Winkler, Ellen Leibenluft, Daniel S Pine, Dylan G Gee

Open access · greenAbstract read
In one paragraph

Article in Behavioural brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Threat Appraisal and Pediatric Anxiety: Proof of Concept of a Latent Variable Approach.Clinical psychological science : a journal of the Association for Psychological Science · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. The Neural Correlates of Cued Reward Omission.Frontiers in human neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Anita HarrewijnEmotion and Development Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA. Electronic address: anita.harrewijn@nih.gov.
Elizabeth R KittEmotion and Development Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Rany AbendEmotion and Development Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Chika MatsumotoEmotion and Development Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Paola OdriozolaDepartment of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, Connecticut 06511, USA.
Anderson M WinklerEmotion and Development Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Ellen LeibenluftEmotion and Development Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Daniel S PineEmotion and Development Branch, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Dylan G GeeDepartment of Psychology, Yale University, 2 Hillhouse Avenue, New Haven, Connecticut 06511, USA.
National Institute of Mental Health · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Novel Mechanisms of Fear Reduction Targeting the Biological State of the Developing BrainDP5OD021370 · OD · YALE UNIVERSITY · PI GEE, DYLAN GRACE · 2015 to 2019
$1.3M
Intramural NIH HHS ZIA MH002782NCATS NIH HHS UL1 TR001863NIH HHS DP5 OD021370
6 · The paper itself

Abstract

Cognitive-behavioral therapy (CBT), a first-line treatment for pediatric anxiety disorders, is based on principles of threat learning and extinction. However, CBT does not work sufficiently for up to 40% of clinically anxious youth. The neural and behavioral correlates of conditioned inhibition might provide promising targets for attempts to improve CBT response. During conditioned inhibition, threat and safety cues appear together, forming a safety compound. Here, we test whether this safety compound elicits a reduced fear response compared to pairing the threat cue with a novel cue (novel compound). The current pilot study compares behavioral, physiological, and neural correlates of conditioned inhibition between children with (n = 17, M

Indexed as

Brain MappingInhibition, PsychologicalAdolescentAmygdalaAnxiety DisordersAuditory PerceptionChildConditioning, ClassicalFearFemaleGalvanic Skin ResponseGyrus CinguliHippocampusHumansMagnetic Resonance ImagingMaleAnxietyConditioned inhibitionDevelopmentExposureFear acquisition

Identifiers

PMID33160010
PMCPMC7855938
OpenAlexW3095414863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.