ArticleProgress in neurobiology2020
The connections of the insular VEN area in great apes: A histologically-guided ex vivo diffusion tractography study.
Article in Progress in neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- An expanded cortical map of von Economo neurons in the human medial prefrontal cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The prefrontal cortex: from monkey to man.Brain : a journal of neurology · 2024Review
- Von Economo neurons: Cellular specialization of human limbic cortices?Journal of anatomy · 2022Review
- Scaling Principles of White Matter Connectivity in the Human and Nonhuman Primate Brain.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Von Economo Neurons - Primate-Specific or Commonplace in the Mammalian Brain?Frontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
We mapped the connections of the insular von Economo neuron (VEN) area in ex vivo brains of a bonobo, an orangutan and two gorillas with high angular resolution diffusion MRI imaging acquired in 36 h imaging sessions for each brain. The apes died of natural causes without neurological disorders. The localization of the insular VEN area was based on cresyl violet-stained histological sections from each brain that were coregistered with structural and diffusion images from the same individuals. Diffusion MRI tractography showed that the insular VEN area is connected with olfactory, gustatory, visual and other sensory systems, as well as systems for the mediation of appetite, reward, aversion and motivation. The insular VEN area in apes is most strongly connected with frontopolar cortex, which could support their capacity to choose voluntarily among alternative courses of action particularly in exploring for food resources. The frontopolar cortex may also support their capacity to take note of potential resources for harvesting in the future (prospective memory). All of these faculties may support insight and volitional choice when contemplating courses of action as opposed to rule-based decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.