Evidence map›Paper›PMID 33159803›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2021

Protease-activated receptor 4 plays a role in lipopolysaccharide-induced inflammatory mechanisms in murine macrophages.

A Barra, K M Freitas, D G Marconato, P Faria-Pinto, M T P Lopes, André Klein

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Proteases in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  3. Serine proteases and protease-activated receptors signaling in the kidney.American journal of physiology. Cell physiology · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A BarraLaboratory of Pain and Inflammation, Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Av. Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-010, Brazil.
K M FreitasLaboratory of Antitumoral Substances, Department of Pharmacology, ICB, UFMG, Belo Horizonte, MG, Brazil.
D G MarconatoProtein Structure and Function Study Laboratory, Department of Biochemistry, ICB, Federal University of Juiz de Fora (UFJF), Juiz de Fora, MG, Brazil.
P Faria-PintoProtein Structure and Function Study Laboratory, Department of Biochemistry, ICB, Federal University of Juiz de Fora (UFJF), Juiz de Fora, MG, Brazil.
M T P LopesLaboratory of Antitumoral Substances, Department of Pharmacology, ICB, UFMG, Belo Horizonte, MG, Brazil.
André KleinLaboratory of Pain and Inflammation, Department of Pharmacology, Institute of Biological Sciences (ICB), Federal University of Minas Gerais (UFMG), Av. Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-010, Brazil. klein@ufmg.br.ORCID 0000-0001-9788-4647

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of protease-activated receptor (PAR)4 in thrombin-induced platelet aggregation has been studied, and PAR4 blockade is thought to be useful as a new and promising approach in antiplatelet therapy in humans. In recent years, studies have been conducted to clarify the role of PAR4 in the host defense against invading microorganisms and pathogen-induced inflammation; however, to date, the role of PAR4 in mediating the LPS-induced inflammatory repertoire in macrophages remains to be elucidated. Here, we investigated the effects of the synthetic PAR4 agonist peptide (PAR4-AP) AYPGKF-NH

Indexed as

AnimalsFemaleFluorescein-5-isothiocyanateInflammationLipopolysaccharidesMacrophagesMiceMice, Inbred C57BLNitric OxideOligopeptidesPhagocytosisReactive Oxygen SpeciesReceptors, ThrombinZymosanalanyl-tyrosyl-prolyl-glycyl-lysyl-phenylalanineFluorescein-5-isothiocyanateLipopolysaccharidesNitric OxideOligopeptidesprotease-activated receptor 4Reactive Oxygen SpeciesReceptors, ThrombinZymosanLPSMacrophage activationMacrophage phagocytosisPAR4Protease-activated receptor-4

Identifiers

PMID33159803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.