ArticleJournal of molecular neuroscience : MN2021
Serum Progesterone and Testosterone Levels in Schizophrenia Patients at Different Stages of Treatment.
Article in Journal of molecular neuroscience : MN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Mapping aggressive behaviors and testosterone among schizophrenia patients in acute stage.Schizophrenia (Heidelberg, Germany) · 2025Article
- 17β-estradiol status alters NMDAR function and antipsychotic-like activity in female rats.Molecular psychiatry · 2025Article
- Gonadal hormone abnormalities in young patients with first-episode schizophrenia.The international journal of neuropsychopharmacology · 2024Article
- Editorial: New insights into investigating schizophrenia as a disorder of molecular pathways.Frontiers in molecular neuroscience · 2024Article
- Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia: A Narrative Review.Clocks & sleep · 2022Review
- Aberrant cortical surface and cognition function in drug-naive first-episode schizophrenia.Annals of general psychiatry · 2022Article
- Effects of Luteinizing Hormone Releasing Hormone A2 on Gonad Development in Juvenile Amur Sturgeon, Acipenser schrenckii, Revealed by Transcriptome Profiling Analysis.Frontiers in genetics · 2022Article
- Attractin Participates in Schizophrenia by Affecting Testosterone Levels.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that dysregulation of hormones is associated with schizophrenia (SCZ). This study aimed to measure the serum levels of progesterone and testosterone in 125 SCZ patients at different stages of treatment and 96 healthy control (HC) subjects. Our results showed that first-episode drug-free SCZ patients had significantly increased testosterone levels when compared with HC subjects, and chronic medication, but not short-term medication, further increased the serum testosterone levels in the patients. Further analysis suggested that the sex of the patients did not affect testosterone levels. In contrast, serum progesterone levels did not show significant differences between first-episode, drug-free SCZ patients and controls, and the antipsychotics increased progesterone levels in the male SCZ patients, but not female patients. Interestingly, our analyses demonstrated that the serum progesterone levels were negatively correlated with PANSS total score and PNASS positive score, suggesting a correlation between blood hormone levels and disease severity in SCZ patients. Taken together, our data showed differential changes in serum testosterone and progesterone levels in SCZ patients with or without antipsychotics, and our results suggest that increased sex hormone levels may be a defensive response to protect the human body under stress.
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Registered trials
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