Evidence map›Paper›PMID 33159638›Full record

ArticleJournal of molecular histology2021

Altered BMP-Smad4 signaling causes complete cleft palate by disturbing osteogenesis in palatal mesenchyme.

Nan Li, Jing Liu, Han Liu, Shangqi Wang, Ping Hu, Hailing Zhou, Jing Xiao, Chao Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Deficiency ofInternational journal of molecular sciences · 2023
    Article
  8. Single cell sequencing of the mouse anterior palate reveals mesenchymal heterogeneity.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. SMAD4 contributes to chondrocyte and osteocyte development.Journal of cellular and molecular medicine · 2022
    Review
  15. Frontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nan LiDalian Key Laboratory of Basic Research in Oral Medicine, School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Jing LiuDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Han LiuDalian Key Laboratory of Basic Research in Oral Medicine, School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Shangqi WangDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Ping HuDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Hailing ZhouDepartment of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Jing XiaoDalian Key Laboratory of Basic Research in Oral Medicine, School of Stomatology, Dalian Medical University, Dalian, 116044, China.
Chao LiuDalian Key Laboratory of Basic Research in Oral Medicine, School of Stomatology, Dalian Medical University, Dalian, 116044, China. cliu@dmu.edu.cn.ORCID http://orcid.org/0000-0002-3584-0224
Dalian Medical University · CN

Funding

National Natural Science Foundation of China 81771055National Natural Science Foundation of China 81970922
6 · The paper itself

Abstract

As the major receptor mediated BMP signaling in craniofacial development, Bmpr1a expression was detected in the anterior palatal shelves from E13.5 and the posterior palatal shelves from E14.5. However, inactivating BMP receptor in the mesenchyme only leads to anterior cleft palate or submucous cleft palate. The role of BMP signaling in posterior palatal mesenchyme and palatal osteogenesis is still unknown. In this study, a secreted BMP antagonist, Noggin was over-expressed by Osr2-cre

Indexed as

OsteogenesisSignal TransductionAnimalsBone and BonesBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsBromodeoxyuridineCarrier ProteinsCell DifferentiationCell ProliferationCleft PalateEmbryo, MammalianIntegrasesMaleMesodermMice, TransgenicBmpr1a protein, mouseBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsBromodeoxyuridineCarrier ProteinsCre recombinaseIntegrasesNoggin ProteinSmad4 ProteinSp7 protein, mouseSp7 Transcription FactorBMP receptorBMP signalingCleft palateNogginOsteogenesisPalatogenesis

Identifiers

PMID33159638
OpenAlexW3097400294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.