Evidence map›Paper›PMID 33159584›Full record

ArticleArchives of toxicology2021

Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide.

Annelies Noorlander, Eric Fabian, Bennard van Ravenzwaay, Ivonne M C M Rietjens

Open access · hybridAbstract read
In one paragraph

Article in Archives of toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Annelies NoorlanderDivision of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. annelies.noorlander@wur.nl.ORCID 0000-0003-2700-9390
Eric FabianExperimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany.
Bennard van RavenzwaayExperimental Toxicology and Ecology, BASF SE, Ludwigshafen, Germany.
Ivonne M C M RietjensDivision of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
BASF (Germany) · DEWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to develop a generic rat physiologically based kinetic (PBK) model that includes a novel testing strategy where active biliary excretion is incorporated using estradiol-17β glucuronide (E

Indexed as

Models, BiologicalAdministration, IntravenousAnimalsBileEstradiolHepatobiliary EliminationHepatocytesProof of Concept StudyRatsRats, Sprague-DawleyEstradiolestradiol-17 beta-glucuronideBiliary excretionPhysiologically based kinetic modellingPrimary rat hepatocytesScaling factor

Identifiers

PMID33159584
PMCPMC7811516
OpenAlexW3095469062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.