Evidence map›Paper›PMID 33159500›Full record

ArticleJournal of cellular and molecular medicine2020

Unique inflammatory signature in haemophilic arthropathy: miRNA changes due to interaction between blood and fibroblast-like synoviocytes.

Sandra Mignot, Nicolas Cagnard, Benoit Albaud, Cécile Bally, Justine Siavellis, Olivier Hermine, Laurent Frenzel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Biomarkers Involved in the Pathogenesis of Hemophilic Arthropathy.International journal of molecular sciences · 2024
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Sandra MignotLaboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris Descartes - Sorbonne Paris Cité University, Labex GR-Ex, Imagine Institute, Inserm U1163, Paris, France.
Nicolas CagnardBioinformatics Platform - Institut IMAGINE, Paris, France.
Benoit AlbaudGenomic Platform - Institut CURIE, Paris, France.
Cécile BallyHematology unit care - hemophilia Center - Necker Hospital, Paris, France.
Justine SiavellisLaboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris Descartes - Sorbonne Paris Cité University, Labex GR-Ex, Imagine Institute, Inserm U1163, Paris, France.
Olivier HermineLaboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris Descartes - Sorbonne Paris Cité University, Labex GR-Ex, Imagine Institute, Inserm U1163, Paris, France.
Laurent FrenzelLaboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications, Paris Descartes - Sorbonne Paris Cité University, Labex GR-Ex, Imagine Institute, Inserm U1163, Paris, France.ORCID 0000-0002-6085-2163
Délégation Paris 5 · FRInserm · FRHôpital Necker-Enfants Malades · FRInstitut Curie · FRInstitut des Maladies Génétiques Imagine · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In haemophilia, the recurrence of hemarthrosis leads to irreversible arthropathy termed haemophilic arthropathy (HA). However, HA is a unique form of arthropathy in which resident cells, such as fibroblast-like synoviocytes (FLS), come into direct contact with blood. Therefore, we hypothesized that FLS in HA could have a unique inflammatory signature as a consequence of their contact with blood. We demonstrated with ELISA and ELISPOT analyses that HA-FLS expressed a unique profile of cytokine secretion, which differed from that of non-HA-FLS, mainly consisting of cytokines involved in innate immunity. We showed that unstable cytokine mRNAs were involved in this process, especially through miRNA complexes as confirmed by DICER silencing. A miRNOME analysis revealed that 30 miRNAs were expressed differently between HA and non-HA-FLS, with most miRNAs involved in inflammatory control pathways or described in certain inflammatory diseases, such as rheumatoid arthritis or lupus. Analysis of transcriptomic networks, impacted by these miRNAs, revealed that protein processes and inflammatory pathways were particularly targeted in LPS-induced FLS, and in particular vascularization and osteoarticular modulation pathways in steady-state FLS. Our study demonstrates that the presence of blood in contact with FLS may induce durable miRNA changes that likely participate in HA pathophysiology.

Indexed as

BiomarkersCell CommunicationCytokinesDisease SusceptibilityEpigenesis, GeneticFibroblastsGene Expression ProfilingGene Expression RegulationHemarthrosisHemophilia AHumansImmunophenotypingInflammation MediatorsMicroRNAsProteomicsSignal TransductionBiomarkersCytokinesInflammation MediatorsMicroRNAscytokinesFLSHaemophiliahaemophilic arthropathymiRNA

Identifiers

PMID33159500
PMCPMC7753994
OpenAlexW3095823427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.