Evidence map›Paper›PMID 33159273›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Breaking the ice to improve motor outcomes in patients with chronic stroke: a retrospective clinical study on neuromodulation plus robotics.

Antonino Naro, Luana Billeri, Alfredo Manuli, Tina Balletta, Antonino Cannavò, Simona Portaro, Paola Lauria, Fabrizio Ciappina, Rocco Salvatore Calabrò

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. A narrative review on non-invasive stimulation of the cerebellum in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Antonino NaroIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Luana BilleriIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Alfredo ManuliIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Tina BallettaIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Antonino CannavòIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Simona PortaroIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Paola LauriaIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Fabrizio CiappinaIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy.
Rocco Salvatore CalabròIRCCS Centro Neurolesi Bonino Pulejo, via Palermo, SS 113, ctr. Casazza, 98124, Messina, Italy. salbro77@tiscali.it.ORCID http://orcid.org/0000-0002-8566-3166

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStroke is one of the main causes of impairment affecting daily activities and quality of life. There is a growing effort to potentiate the recovery of functional gait and to enable stroke patients to walk independently.

aimTo estimate the effects of dual-site transcranial direct current stimulation (dstDCS) on gait recovery in chronic stroke patients provided with robot-aided gait training (RAGT).

methodsThirty-seven patients were included in this retrospective clinical study. Nine patients were provided with dstDCS during the first 10 min of RAGT by using Lokomat®Pro (on-RAGT), 15 patients immediately after RAGT (post-RAGT), and 13 patients immediately before RAGT (pre-RAGT).

resultsEach group improved over time concerning disability burden and lower limb strength. on-RAGT and post-RAGT experienced better improvement in balance (p < 0.001) and, moderately, gait endurance (p = 0.04) as compared to pre-RAGT. Furthermore, all treatments decreased the facilitation of the unaffected hemisphere (p < 0.001) and the inhibition of the affected hemisphere (p < 0.001). The duration of such aftereffects was found to be greater for post-RAGT. DISCUSSION AND

conclusionThis is the first trial with dstDCS coupled with RAGT in chronic stroke patients with gait impairment. When timely coupled with RAGT, dstDCS may be considered an effective tool for the recovery of lower limb function in patients with first unilateral stroke in the chronic phase. Moreover, our data suggest the ductility of dstDCS concerning RAGT timing, thus making this intervention suitable in a neurorehabilitation setting and well adaptable to patients' needs.

Indexed as

Gait Disorders, NeurologicRoboticsStrokeStroke RehabilitationTranscranial Direct Current StimulationExercise TherapyGaitHumansQuality of LifeRetrospective StudiesChronic strokeDual-site transcranial direct current stimulationGait recoveryRobot-aided gait training

Identifiers

PMID33159273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.